Archive for the 'Causation' Category
Articles dealing with the factors influencing the development of mesothelioma; occupational asbestos exposure is among the most common, but also genetic predisposition, smoking, and other contributing factors.
August 8th, 2008. Sensitivity analysis of the relationship between disease occurrence and distance from a putative source of pollution
However, as the models appeared to be sensitive to modeling choices, we suggest that any analysis of disease risk around a putative source should be integrated with a careful sensitivity analysis and possibly with prior knowledge. The choice of prior distribution is extremely important and should be based on epidemiological considerations.
August 1st, 2008. Update of Potency Factors for Asbestos-Related Lung Cancer and Mesothelioma
, chrysotile or crocidolite) of an asbestos structure. An analysis is conducted to determine how well different KL and KM definitions are able to reconcile the discrepancies observed herein among values obtained from different environments.
July 30th, 2008. Pathogenesis of malignant pleural mesothelioma and the role of environmental and genetic factors
However, the late stage of MPM diagnosis and the long latency that exists between some exposures and diagnosis have made it difficult to comprehensively evaluate the role of risk factors and their downstream molecular effects. In this review, we discuss the current molecular and genetic contributors in MPM pathogenesis and the risk factors associated with these carcinogenic processes.
July 26th, 2008. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study
This is of considerable importance, because research and business communities continue to invest heavily in carbon nanotubes for a wide range of products under the assumption that they are no more hazardous than graphite. Our results suggest the need for further research and great caution before introducing such products into the market if long-term harm is to be avoided.
July 25th, 2008. Environmental exposure to Libby asbestos and mesotheliomas
Results: These exposures are considered to be of a low degree of magnitude, but are similar to those in Western Australia's crocidolite mine at Wittenoom Gorge. An epidemic of mesothelioma can likely be expected from this type of asbestos contamination over the next 20 plus years.
July 22nd, 2008. Assessment of biomarkers in asbestos-exposed workers as indicators of cancer risk
Subjects heavily exposed to asbestos [>60(ff/cm(3))xyears] showed also a higher level of angiogenic factors. A combination of angiogenic biomarkers with a specific mesothelioma-biomarker such as SMRPs could be used for close surveillance of workers with a history of asbestos exposure.
July 1st, 2008. Malignant mesothelioma with heterologous elements: clinicopathological correlation of 27 cases and literature review
Immunohistochemical labelling for cytokeratins is helpful in the distinction, but lack of labelling for cytokeratins in a spindle cell/sarcomatoid tumour does not exclude the diagnosis of mesothelioma, irrespective of the presence of heterologous elements. We suggest that if the anatomical distribution conforms to that of mesothelioma, a diagnosis of heterologous mesothelioma should be made in preference to a diagnosis of primary pleural osteosarcoma or chondrosarcoma, regardless of cytokeratin positivity, as for conventional non-heterologous sarcomatoid mesothelioma.
Posted in Biphasic or Mixed, Causation, Diagnosis & Differentiation, Epithelioid, Full Archive, General, Immunohistochemistry or IHC, Peritoneal (Abdominal Mesothelioma), Pleural, Sarcomatoid, Survival, Type of Assessment:, Type of Mesothelioma: | No Comments »
June 28th, 2008. Mesothelioma and Asbestos-Related Pleural Diseases
We summarized the most relevant data for the diagnosis and the management of benign asbestos pleural effusions, pleural plaques, diffuse pleural thickening and rounded atelectasis. Special attention is dedicated to malignant pleural mesothelioma, given the challenging issues of this disease, the recent advances in its management and the dynamism of research in this area.
June 25th, 2008. Asbestos Fibre Concentrations in the Lungs of Brake Workers: Another Look
Conclusions: Re-analysis of published data does not support the interpretation that, in automotive brake repair workers with malignant mesothelioma, asbestos content is within the normal range. The alternative interpretation that brake mechanics have a greater than background burden of asbestos fibres, attributable to occupational exposure to dusts from friction products manufactured from Canadian chrysotile, appears more credible. This asbestos burden might be associated with an increased risk of asbestos-associated cancers.
June 24th, 2008. Separation and Characterization of Respirable Amphibole Fibers from Libby, Montana
Such harvesting of respirable fractions will allow toxicological studies to be conducted within a controlled laboratory setting, utilizing fiber sizes that may more accurately simulate historical exposure of Libby residents' lungs. Importantly, this work describes a method that allows the use of material enriched in more uniform respirable material than raw Libby 6-mix, making comparisons with other known fiber preparations more valid on a mass basis.
June 24th, 2008. Select mortality and cancer incidence among residents in various U.S. communities that received asbestos-contaminated vermiculite ore from Libby, Montana
No statistically significant excesses of asbestosis mortality similar to those in Libby were noted; however, 11 sites (plus a state with 6 pooled sites that were counted as 1 site) had excess rates of mesothelioma and cancer of the peritoneum, retroperitoneum, and pleura. Further investigation should be conducted at these sites with excess rates of mesothelioma and cancer of the peritoneum, retroperitoneum, and pleura by participating state health departments to determine whether exposure to Libby vermiculite might have been a contributing factor.
June 24th, 2008. Asbestos Burden Predicts Survival in Pleural Mesothelioma
Conclusion: Our data suggest that patient survival is associated with asbestos fiber burden in MPM and is perhaps modified by susceptibility.
June 24th, 2008. Mesothelioma: a still current occupational cancer
In certain circumstances compensation can be obtained at the Occupational Diseases Found. The renewed interest with regard to this tumour is supported by the improvement of mesothelioma management, the new imaging techniques, the new treatments and the broad diffusion of information related to the risk of developing this tumour following asbestos inhalation.
June 17th, 2008. Mapping the Risk of Mesothelioma due to Neighborhood Asbestos Exposure
Conclusions: Neighborhood exposure to asbestos can pose a serious risk to residents across a wide area.
June 15th, 2008. SV40 large T antigen-specific human T cell memory responses
Peptide-stimulated T cells also killed SV40 Tag-transfected target cells. This article demonstrates the presence, and provides a detailed analysis, of SV40-specific T cell memory in man.
June 11th, 2008. Pemetrexed plus carboplatin in elderly patients with malignant pleural mesothelioma: combined analysis of two phase II trials
Apart from slightly worse haematological toxicity, there was no significant difference in outcome or toxicity between age groups. The PC regimen is effective and well tolerated in selected elderly patients with MPM.
Posted in Carboplatin, Causation, Chemotherapy, Determining Efficacy, Diagnosis & Differentiation, Epidemiological, Full Archive, Immunohistochemistry or IHC, Occupational Asbestos Exposure, Pemetrexed (Alimta), PET Scan, Pleural, Treatment, Type of Assessment: | No Comments »
June 6th, 2008. Excess of Mesotheliomas after Exposure to Chrysotile in Balangero, Italy
Conclusions: The cluster of 14 mesothelioma cases among workers who were active in the mine and 13 among other people exposed to Balangero chrysotile adds further evidence to the carcinogenicity of tremolite-free chrysotile.
June 6th, 2008. Long-term mortality from pleural and peritoneal cancer after exposure to asbestos: Possible role of asbestos clearance
The risk for pleural cancer, rather than showing an indefinite increase, might reach a plateau when a sufficiently long time has elapsed since exposure. The different trends for pleural and peritoneal cancer might be related to clearance of the asbestos from the workers' lungs.
Posted in Causation, Determining Efficacy, Diagnosis & Differentiation, Epidemiological, Full Archive, Imatinib Mesylate (Gleevec/Glivec), Intraperitoneal Chemotherapy, melphalan, Occupational Asbestos Exposure, Oxaliplatin (Eloxatin), paclitaxel, PET Scan, Pleural, Pleural Catheters, Proton Beam Therapy, Staging, Symptoms & Symptom Management, Treatment, Type of Assessment: | No Comments »
June 4th, 2008. An autopsy case of diffuse pleural thickening presented respiratory impairment and benign asbestos pleurisy
The autopsy disclosed asbestos-related lung diseases. We suspected that diffuse pleural thickening could be a major cause of fatal respiratory impairment in this case.
Posted in Case Study, Causation, CT or CAT scan, Diagnosis & Differentiation, Full Archive, Occupational Asbestos Exposure, Pleural Biopsy, Pleural Effusion, Symptoms & Symptom Management, thoracoscopy, Type of Assessment: | No Comments »
June 4th, 2008. Malignant mesothelioma 2008
Novel therapies including intrapleural chemotherapy, photodynamic therapy and hyperthermic perfusion have also been used with some success. Finally there are several attempts at immunomodulating and targeted treatments, which are in phase I/II trials.
Posted in Causation, Chemotherapy, Determining Efficacy, Diagnosis & Differentiation, Full Archive, General, Immune-based Therapies, New & Novel, Occupational Asbestos Exposure, Photodynamic Therapy (PDT), Radiation, Serum Marker/Blood Test, Survival, SV40, Treatment, Type of Assessment: | No Comments »
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