Archive for the 'Causation' Category
Articles dealing with the factors influencing the development of mesothelioma; occupational asbestos exposure is among the most common, but also genetic predisposition, smoking, and other contributing factors.
September 30th, 2008. Acrylamide Carcinogenicity
The mode of action remains unclear for acrylamide-induced rodent carcinogenicity, but support for a genotoxic mechanism based on in vitro and in vivo DNA reactivity assays cannot be ruled out. In addition, the pattern of tumor formation in the rat following chronic exposure supports a genotoxic mode of action but also suggests a potential role of endocrine modification.
September 27th, 2008. Treatment of peritoneal mesothelioma in pediatric patients
Treatment was well tolerated, and three of these patients have achieved long-term survival. The fathers of three of the patients worked in the construction industry and may have been the source of indirect asbestos exposure.
Posted in Case Study, Causation, Cisplatin (Platinol ®), Determining Efficacy, Full Archive, Occupational Asbestos Exposure, Peritoneal (Abdominal Mesothelioma), Survival, Treatment, Type of Assessment:, Type of Mesothelioma: | 2 Comments »
September 24th, 2008. The relationship between malignant mesothelioma and an asbestos cement plant environmental risk: a spatial case–control study in the city of Bari (Italy)
Conclusion: Evidence of an association between mesothelioma risk and EAE is highlighted. The role played by the RMR in increasing the public health local authorities awareness is stressed. Keywords Asbestos-cement plant - Environmental-neighborhood exposure - Mesothelioma register - Spatial case–control study - Public health - Italy
September 23rd, 2008. Predicted mortality from malignant mesothelioma among women exposed to blue asbestos at Wittenoom, Western Australia
Conclusion: The high toll from mesothelioma in this cohort of women and girls will continue well into the future.
September 17th, 2008. Orally Ingested Chrysotile Asbestos Affects Rat Lungs and Pleura
The authors observed mesothelial proliferation in all group B rats at the end of 12 months. Ingested asbestos traveled from the gastrointestinal system to the lungs, likely via a lymphohematological route, leading to mesothelial proliferation, which may lead to malignancies.
September 17th, 2008. Raw single-wall carbon nanotubes induce oxidative stress and activate MAPKs, AP-1, NF-kappaB, and Akt in normal and malignant human mesothelial cells
Conclusions: The cellular and molecular findings reported here do suggest that SWCNTs can cause potentially adverse cellular responses in mesothelial cells through activation of molecular signaling associated with oxidative stress, which is of sufficient significance to warrant in vivo animal exposure studies.
September 13th, 2008. Pathogenesis of malignant pleural mesothelioma and the role of environmental and genetic factors
Conclusion: Many risk factors for MPM development have been recognized including environmental exposures, genetic susceptibility, viral contamination, and radiation. In this review, we discuss the current molecular and genetic contributors to MPM pathogenesis and the risk factors associated with these carcinogenic processes.
September 9th, 2008. Characteristics and modifying factors of asbestos-induced oxidative DNA damage
p. chrysotile, our data suggest that asbestos-associated catalytic iron, whether constitutional or induced by other mechanisms, plays an important role in asbestos-induced carcinogenesis and that chemoprevention may be possible through targeting the catalytic iron.
September 9th, 2008. Clinical consequences of asbestos-related diffuse pleural thickening: A review
It causes a restrictive defect on lung function and may rarely result in respiratory failure and death. Treatment is primarily supportive.
Posted in Causation, CT or CAT scan, Diagnosis & Differentiation, Environmental Asbestos Exposure, Full Archive, Occupational Asbestos Exposure, PET Scan, Pleural Effusion, Symptoms & Symptom Management, Treatment, Type of Assessment: | No Comments »
September 5th, 2008. Asbestos Surveillance Program Aachen (ASPA): initial results from baseline screening for lung cancer in asbestos-exposed high-risk individuals using low-dose multidetector-row CT
28% (8/187) at baseline screening with an additional large number of indeterminate pulmonary nodules. Low-dose MDCT proved to be feasible in this highly selected population.
September 2nd, 2008. The role of polio-vaccine in pleural mesothelioma–an epidemiological observation
This is the opposite to what would be expected if potential SV40 contamination of polio vaccine used had a causative role in the development of the tumour. On the other hand, shorter latency period reflected by very high percentage of 45-year-old or younger mesothelioma patients in vaccinated group (15 out of 58), with all of them having a history of occupational asbestos exposure, raises a question for a possible enhancing effect of the vaccine used to asbestos exposure, if it was contaminated with SV40.
August 30th, 2008. Occupational exposure to asbestos and mortality among asbestos removal workers: a Poisson regression analysis
This study is a first step in assessing long-term mortality of asbestos removal workers in relation to working practices and asbestos exposure. Further follow-up will allow the impact of recent regulations to be assessed.
August 23rd, 2008. Asbestos clinics and asbestos health examinations–findings from a questionnaire survey of implementing organizations
The organizations we surveyed have important roles to play. Although resources are limited, effective diagnosis and treatment are essential, and a system assisting organizations to make accurate and efficient identification of asbestos exposure hazards is imperative.
August 19th, 2008. Mesothelioma Epidemiology, Carcinogenesis, and Pathogenesis
An exciting new development comes from the discovery that genetic susceptibility to mineral fiber carcinogenesis plays a critical role in the incidence of this cancer in certain families. It is hoped that the identification of this putative mesothelioma gene will lead to novel mechanistically driven preventive and therapeutic approaches.
August 12th, 2008. Malignant mesothelioma in garment sewing-machine workers
Conclusion: The results of this investigation suggest assigning at least "possible occupational asbestos exposure" to those cases employed in clothing manufacture since the 1950's, who used sewing-machines or pressing machines, according to the Re.Na.M guidelines. Other possible occupational exposures to asbestos in this working sector cannot be excluded; when the simple interview of patients does not reveal such exposures further investigations are needed in order to demonstrate all the possible circumstances of exposure.
August 9th, 2008. Mesothelioma mortality in Brazil, 1980-2003
Mortality was highest among males and people over age 65. Given the history of asbestos exposure in Brazil, our findings support the need for policies that limit or ban the use of this product.
August 8th, 2008. A Meta-Analysis of Asbestos-Related Cancer Risk That Addresses Fiber Size and Mineral Type
(2007) recently analyzed by TEM archived air samples from the South Carolina plant to determine a detailed distribution of fiber lengths up to lengths of 40 μ m and greater. If similar data become available for Quebec, perhaps these two size distributions can be used to eliminate the discrepancy between these two studies.
August 8th, 2008. Sensitivity analysis of the relationship between disease occurrence and distance from a putative source of pollution
However, as the models appeared to be sensitive to modeling choices, we suggest that any analysis of disease risk around a putative source should be integrated with a careful sensitivity analysis and possibly with prior knowledge. The choice of prior distribution is extremely important and should be based on epidemiological considerations.
August 8th, 2008. Novel Functional View of the Crocidolite Asbestos-Treated A549 Human Lung Epithelial Transcriptome Reveals an Intricate Network of Pathways with Opposing Functions
Conclusions: Our analyses demonstrate the power of combining a statistically robust, comprehensive dataset and a functional network genomics approach to 1) identify and explore relationships between genes of known importance 2) identify novel candidate genes, and 3) observe the complex interplay between genes/gene products that function in seemingly different processes. This study represents the first function-based global approach toward understanding the response of human lung epithelial cells to the carcinogen crocidolite. Importantly, our investigation paints a much broader landscape for the crocidolite response than was previously appreciated and reveals novel paths to study. Our graphical representations of the function-based global network will be a valuable resource to model new research findings.
August 8th, 2008. A Meta-Analysis of Asbestos-Related Cancer Risk That Addresses Fiber Size and Mineral Type
(2007) recently analyzed by TEM archived air samples from the South Carolina plant to determine a detailed distribution of fiber lengths up to lengths of 40 μ m and greater. If similar data become available for Quebec, perhaps these two size distributions can be used to eliminate the discrepancy between these two studies.
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