Journal Articles on Mesothelioma: 'Causation' Category
Articles dealing with the factors influencing the development of mesothelioma; occupational asbestos exposure is among the most common, but also genetic predisposition, smoking, and other contributing factors.
June 24th, 2008. Select mortality and cancer incidence among residents in various U.S. communities that received asbestos-contaminated vermiculite ore from Libby, Montana
No statistically significant excesses of asbestosis mortality similar to those in Libby were noted; however, 11 sites (plus a state with 6 pooled sites that were counted as 1 site) had excess rates of mesothelioma and cancer of the peritoneum, retroperitoneum, and pleura. Further investigation should be conducted at these sites with excess rates of mesothelioma and cancer of the peritoneum, retroperitoneum, and pleura by participating state health departments to determine whether exposure to Libby vermiculite might have been a contributing factor.
June 24th, 2008. Asbestos Burden Predicts Survival in Pleural Mesothelioma
Conclusion: Our data suggest that patient survival is associated with asbestos fiber burden in MPM and is perhaps modified by susceptibility.
June 24th, 2008. Mesothelioma: a still current occupational cancer
In certain circumstances compensation can be obtained at the Occupational Diseases Found. The renewed interest with regard to this tumour is supported by the improvement of mesothelioma management, the new imaging techniques, the new treatments and the broad diffusion of information related to the risk of developing this tumour following asbestos inhalation.
June 17th, 2008. Mapping the Risk of Mesothelioma due to Neighborhood Asbestos Exposure
Conclusions: Neighborhood exposure to asbestos can pose a serious risk to residents across a wide area.
June 15th, 2008. SV40 large T antigen-specific human T cell memory responses
Peptide-stimulated T cells also killed SV40 Tag-transfected target cells. This article demonstrates the presence, and provides a detailed analysis, of SV40-specific T cell memory in man.
June 11th, 2008. Pemetrexed plus carboplatin in elderly patients with malignant pleural mesothelioma: combined analysis of two phase II trials
Apart from slightly worse haematological toxicity, there was no significant difference in outcome or toxicity between age groups. The PC regimen is effective and well tolerated in selected elderly patients with MPM.
Posted in Carboplatin, Causation, Chemotherapy, Determining Efficacy, Diagnosis & Differentiation, Epidemiological, Full Archive, Immunohistochemistry or IHC, Occupational Asbestos Exposure, PET Scan, Pemetrexed (Alimta), Pleural, Treatment, Type of Assessment: | No Comments »
June 6th, 2008. Excess of Mesotheliomas after Exposure to Chrysotile in Balangero, Italy
Conclusions: The cluster of 14 mesothelioma cases among workers who were active in the mine and 13 among other people exposed to Balangero chrysotile adds further evidence to the carcinogenicity of tremolite-free chrysotile.
June 6th, 2008. Long-term mortality from pleural and peritoneal cancer after exposure to asbestos: Possible role of asbestos clearance
The risk for pleural cancer, rather than showing an indefinite increase, might reach a plateau when a sufficiently long time has elapsed since exposure. The different trends for pleural and peritoneal cancer might be related to clearance of the asbestos from the workers' lungs.
Posted in Causation, Determining Efficacy, Diagnosis & Differentiation, Epidemiological, Full Archive, Imatinib Mesylate (Gleevec/Glivec), Intraperitoneal Chemotherapy, Occupational Asbestos Exposure, Oxaliplatin (Eloxatin), PET Scan, Pleural, Pleural Catheters, Proton Beam Therapy, Staging, Symptoms & Symptom Management, Treatment, Type of Assessment:, melphalan, paclitaxel | No Comments »
June 4th, 2008. An autopsy case of diffuse pleural thickening presented respiratory impairment and benign asbestos pleurisy
The autopsy disclosed asbestos-related lung diseases. We suspected that diffuse pleural thickening could be a major cause of fatal respiratory impairment in this case.
Posted in CT or CAT scan, Case Study, Causation, Diagnosis & Differentiation, Full Archive, Occupational Asbestos Exposure, Pleural Biopsy, Pleural Effusion, Symptoms & Symptom Management, Type of Assessment:, thoracoscopy | No Comments »
June 4th, 2008. Malignant mesothelioma 2008
Novel therapies including intrapleural chemotherapy, photodynamic therapy and hyperthermic perfusion have also been used with some success. Finally there are several attempts at immunomodulating and targeted treatments, which are in phase I/II trials.
Posted in Causation, Chemotherapy, Determining Efficacy, Diagnosis & Differentiation, Full Archive, General, Immune-based Therapies, New & Novel, Occupational Asbestos Exposure, Photodynamic Therapy (PDT), Radiation, SV40, Serum Marker/Blood Test, Survival, Treatment, Type of Assessment: | No Comments »
June 4th, 2008. The relationship between simian virus 40 and mesothelioma
Epidemiological data possibly linking simian virus 40 and malignant mesothelioma is lacking owing to unattainable identification of infected from noninfected cohorts. Summary: Available evidence appears sufficient to link simian virus 40 either alone or in conjunction with asbestos in causing malignant mesotheliomas; however, it is still insufficient to speculate about the contribution of simian virus 40 to the overall incidence of malignant mesotheliomas.
June 4th, 2008. Mesothelioma due to environmental exposure to erionite in Turkey
It has also been confirmed that a genetic predisposition to erionite carcinogenesis is the cause of the mesothelioma epidemic in Cappadocia. Summary: The data obtained recently on the epidemiology, etiology, and pathogenesis of the mesothelioma due to erionite exposure in Turkey are described.
May 30th, 2008. Two cases of asbestosis and one case of rounded atelectasis due to non-occupational asbestos exposure
The three cases indicate that non-neoplastic, long-latency asbestos-related diseases which are usually observed as a consequence of occupational exposures, may rarely develop in subjects living in contaminated geographical sites and buildings. These unusual environmental diseases raise the diagnostic problem of differentiating them from other, more common respiratory illnesses, and impose the duties of patient notification, assessment and follow-up, to assess the possibility of progression of disease and increased neoplastic risk.
May 29th, 2008. Malignant mesothelioma of the tunica vaginalis testis in a petrochemical worker exposed to asbestos
Tunical mesothelioma may simulate metastatic carcinoma at routine histopathological examination. Immunohistochemistry and occupational anamnesis are helpful for the correct diagnosis, which, in turn, is important for prognosis and treatment, and in relation to legal issues when asbestos is involved in the causation of the disease.
Posted in Case Study, Causation, Diagnosis & Differentiation, Epithelioid, Full Archive, Immunohistochemistry or IHC, Occupational Asbestos Exposure, Surgery, Treatment, Tunica Vaginalis Testis, Type of Assessment:, Type of Mesothelioma: | No Comments »
May 29th, 2008. Erionite-induced pleural plaques : Exposition to urban pollution in a female Turkish migrant in Germany
Short-term clinical and radiologic control of the patient will be necessary because of the risk of MPM. For epidemiologic considerations discussed referring to current literature, a growing incidence of this type of disease in migrants from high-risk areas must be reckoned with in Germany, even without exposition to asbestos.
May 23rd, 2008. Circulating Adiponectin Levels and Expression of Adiponectin Receptors in Relation to Lung Cancer: Two Case-Control Studies
Conclusions: Circulating adiponectin levels are not different in cases of this malignancy - which seems to be unrelated to obesity and insulin resistance - compared to their healthy controls, though hormonal levels were significantly lower in advanced versus limited lung cancer. Both adiponectin receptors were expressed in cancerous lung tissue, but not in normal control tissue and there was a differential expression by disease stage. These findings should be further explored, especially in the context of the recently reported protective effect of thiazolidinediones in diabetic patients with lung cancer.
May 23rd, 2008. Multiple roles of nicotine on cell proliferation and inhibition of apoptosis: Implications on lung carcinogenesis
These observations led to the hypothesis that nicotine might be playing a direct role in the promotion and progression of human lung cancers. Here, we briefly overview the role and the effects of nicotine on pulmonary cell growth and physiology and its feasible implications in lung carcinogenesis.
May 22nd, 2008. Railways and Asbestos in Japan (1928-1987) -Epidemiology of Pleural Plaques, Malignancies and Pneumoconioses
Two cases of mesothelioma were reported in 1980. Pneumoconioses: Most studies (1928-1975) had relatively low prevalence rates among SL-related workers.
May 22nd, 2008. Trends in suspected and recognized occupational respiratory diseases in Germany between 1970 and 2005.
Conclusions: Although trends in occupational disease may be influenced by several factors, the presented data indicate that prevention has been effective in reducing some of the most frequent occupational respiratory diseases in Germany.
May 21st, 2008. The defence of chrysotile, 1912-2007
Rather, the inquiries constituted elements in the industry's successful public relations exercise that continues to operate to this day. Even when an increasing number of national bodies have legislated for total bans on asbestos use, a policy with which all the international bodies concerned with public health agree, the Canadian PR apparatus continues to be able to call on physicians and scientists prepared to oppose the consensuses reached by the independent advisors to these bodies.
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