Archive for the 'Environmental Asbestos Exposure' Category
August 28th, 2007. Burden of major cancers on years of life lost with premature death in crocidolite-contaminated area in Dayao
Conclusion: Lung cancer, liver cancer, mesothelioma, leukemia and breast cancer are the major cancers with an important impact on people's health and premature mortality in the environmental crocidolite-contaminated area. The impact of cancer mortality is more severer in those aged over 45 years. Social burden of cancer is the greatest in persons aged from 15 to 59 years. Policies and plans should be worked out for the protection of environment and the prevention of cancer.
August 8th, 2007. Fatal legacy of asbestos
Abstract Mesothelioma is a fatal disease with no cure. Thousands have contracted it unwittingly through their job, environment or those they live with.
July 20th, 2007. Modeling Mesothelioma Risk Associated with Environmental Asbestos Exposure
Conclusions: This study provides strong evidence that asbestos pollution from an industrial source greatly increases mesothelioma risk. Furthermore, relative risks from occupational exposure were underestimated and were markedly increased when adjusted for residential distance.
July 6th, 2007. Evaluation of simian virus-40 as a biological prognostic factor in Egyptian patients with malignant pleural mesothelioma
SV40 and asbestos exposure are common in Egyptian MPM, denoting a possible etiological role and a synergistic effect for both agents. Combined positivity for SV40 and asbestos exposure is an independent prognostic factor in MPM, having a detrimental effect on OS.
June 19th, 2007. Mesothelioma mortality in Greece from 1983 to 2003
Conclusion: Our data suggest a change in the balance of risk away from traditional asbestos exposure industries to industries where one could describe the exposure as secondary such as plumbers, technicians, drivers, farmers. Also, we found out that the higher cause-specific mortality rate was 0.38/100,000 population in Epirus, the lower was 0.025/100,000 in Thessalia and the national average rate was 0.10/100,000 population.
June 19th, 2007. Risk of developing mesothelioma due to neighborhood exposure to asbestos
As a whole, relative risk (RR) of neighborhood exposure in crocidolite and amosite mines was about 10 to 30 and RR in major asbestos factories was about 5 to 20. On the other hand, statistically significant RR of neighborhood exposure was not observed in chrysotile mines and some asbestos facilities.
June 15th, 2007. Asbestos exposure and differences in occurrence of peritoneal mesothelioma in the Netherlands and Sweden
Conclusion: The absence of a time trend in the incidence rate of peritoneal mesothelioma in the Netherlands and Sweden in the past 15 years may point at a more limited role of occupational exposure to asbestos in the etiology of peritoneal mesothelioma than for pleural mesothelioma, especially among women. The observed drop around 2000 in annual incidence of peritoneal mesothelioma among Swedish women indicates the presence in the past of a substantial misclassification with other tumours in the peritoneum.
Posted in Causation, Diagnosis & Differentiation, Environmental Asbestos Exposure, Epidemiological, Full Archive, General, Occupational Asbestos Exposure, Peritoneal (Abdominal Mesothelioma), Pleural, Type of Assessment:, Type of Mesothelioma: | No Comments »
June 2nd, 2007. Recent discovery of an old disease: Malignant pleural mesothelioma in a village in south-east Turkey
Conclusion: The current findings suggest that environmental asbestos exposure continue to be a serious health concern in the Gaziantep region of Turkey.
May 31st, 2007. Diagnostic biomarker of asbestos-related mesothelioma: Example of translational research
Asbestos-related mesothelioma should be ascribed as a typical environmental carcinogen. In this review, we will present asbestos-related mesothelioma for the study of problems in environmental carcinogenesis.
May 31st, 2007. The risk of mesothelioma from exposure to chrysotile asbestos
Although scientific efforts and legal arguments continue, the risk of pleural mesothelioma in human populations is probably negligible for exposures to airborne chrysotile asbestos that is not known to be contaminated by amphibole. This distinction for asbestos fiber types is pivotal for understanding hazards and characterizing risks of continued use of natural chrysotile asbestos today and also new nanofibers.
May 22nd, 2007. Some Limitations of Aggregate Exposure Metrics
Under these conditions, which are not uncommon in practice, aggregate exposure metrics may be "worse than useless," in that risk-management decisions based on them are less effective than decisions that ignore the aggregate exposure information and select risk-management actions at random. The potential practical significance of these results is illustrated by a case study of 27 exposure scenarios in El Dorado Hills, California, where applying an aggregate unit risk factor (from EPA's IRIS database) to aggregate exposure metrics produces average risk estimates about 25 times greater—and of uncertain predictive validity—compared to risk estimates based on specific components of the mixture that have been hypothesized to pose risks of human lung cancer and mesothelioma.
April 26th, 2007. Malignant mesothelioma of the pleura and other malignancies in the same patient
Conclusions: In contrast with other series of the literature, in the present cases the co-existence of mesothelioma and other malignancies appeared as a relatively frequent event. The lack of a control group does not allow definite conclusions about the meaning of the occurrence. However, the co-existence of certain tumors with asbestos-related mesothelioma suggests that mesothelioma and associated malignancies might share some etiologic factors (asbestos and others).
April 24th, 2007. Projected mesothelioma incidence in men in New South Wales
Conclusions: The pattern of parameter estimates in the two models was in accord with the known use of amphibole asbestos in Australia. The predicted peak year of 2014-2021 is 30 to 35 years after the phasing out of amphibole use, and this period is in accord with predictions for the UK and the US; in the latter country the peak was 10 to 15 years earlier corresponding to a discontinuation of amphibole use in the 1960s.
April 5th, 2007. Mesothelioma in blood related subjects: report of 11 clusters among 1954 Italy cases and review of the literature
Conclusions: Available data support asbestos exposure as the main risk factor in mesothelioma cases among blood relatives. Our finding of a low proportion of familial cases would not suggest the influence of a large genetic component for mesothelioma in blood relatives.
March 31st, 2007. Non-occupational malignant pleural mesothelioma due to asbestos and non-asbestos fibres
Conclusion: It is likely that genetic predisposition and non-occupational exposure to low doses of asbestos and asbestos-like fibres may concur to the development of malignant mesothelioma. However, additional epidemiological and laboratory studies are needed to further understand the relationship between environmental exposure and individual susceptibility to this malignancy.
March 27th, 2007. Assessment of asbestos in drinking water in Alexandria, Egypt
No fibers detected in regions, where the pipe distribution system was poly venyl pipe system or changed from A/C pipe to cast iron pipe system. The determination of asbestos fibers in drinking water of Alexandria should have particular concern because of the health hazards that might be associated with their presence.
March 17th, 2007. Investigation of micronucleus frequencies in lymphocytes of inhabitants environmentally exposed to chrysotile asbestos
05). Although the detection of calcified pleural plaques found in the inhabitants has indicated environmental exposure to chrysotile asbestos, our results show that chrysotile asbestos was not an inducer of MN in subjects exposed to chrysotile asbestos.
March 14th, 2007. Ecological association between asbestos-related diseases and historical asbestos consumption: an international analysis
Interpretation: Within the constraints of an ecological study, clear and plausible associations were shown between deaths from the studied diseases and historical asbestos consumption, especially for all mesothelioma in both sexes and asbestosis in men. Our data strongly support the recommendation that all countries should move towards eliminating use of asbestos.
March 14th, 2007. Erionite and asbestos differently cause transformation of human mesothelial cells
Our results reveal that erionite is able per se to turn HMC into transformed highly proliferating cells and disclose the carcinogenic properties of erionite, prompting for a careful evaluation of environmental exposure to these fibers. The genetic predisposition to the effect of erionite is a separate subject for investigation.
March 3rd, 2007. Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines
Conclusion: This study identifies several interesting targets for further investigation in relation to asbestos-associated diseases.
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