Archive for the 'Causation' Category
Articles dealing with the factors influencing the development of mesothelioma; occupational asbestos exposure is among the most common, but also genetic predisposition, smoking, and other contributing factors.
November 26th, 2008. Etiology, epidemiology, biology. Occupational respiratory cancers
In contrast, the search for an occupational exposure that should be routine in all cases of lung cancer, is generally more difficult because of the number of occupational aetiological factors and the absence of criteria that allow distinction of an occupational cancer from a tobacco related one. Therefore attention should be paid to the identification of occupational exposure in order to set up primary prevention programmes to prevent exposure still present in the working environment and, on the other hand, to identify the subjects entitled to the acknowledgement of occupational disease and/or to obtain the compensation available to asbestos victims.
October 31st, 2008. Crocidolite and Mesothelioma
The authors performed a detailed analysis of cases in which crocidolite was identified in the absence of amosite. Most of such cases were identified in recent years, a finding of concern since crocidolite is considered the most potent fiber type with respect to the pathogenesis of mesothelioma.
October 23rd, 2008. The mortality of women exposed environmentally and domestically to blue asbestos at Wittenoom, Western Australia
Conclusion: Women who were former residents of Wittenoom, exposed to asbestos in their environment or in their home, have excess cancer mortality, including mesothelioma, compared with the Western Australian female population.
October 22nd, 2008. A case of non-tuberculous mycobacteriosis with pleurisy with a past history of dense exposure to environmental asbestos
A final diagnosis of NTM was confirmed via open biopsy of the lung. Our case suggests that in addition to tuberculosis, NTM should be taken into consideration as a complication of silicosis.
October 18th, 2008. Lung fiber burden in the Nottingham gas mask cohort
The decline in concentrations with time confirms the hypothesis that crocidolite and, by inference, other amphibole fibers are slowly removed from the lung, but since the longer more carcinogenic fibers were cleared more slowly it is unclear to what extent this clearance explains the slowing down of the increase in mesothelioma mortality from about 40 years from the most recent exposure. The exact biostatistical models which most closely conform with the data remain open to question.
October 10th, 2008. Mortality from Occupational Exposure to Relatively Pure Chrysotile: A 39-Year Study
Conclusions: Occupational exposure to relatively pure chrysotile within permissible levels was not associated with a significant increase in lung cancer or with mesothelioma. Decreased overall mortality of workers indicates a healthy worker effect, which - together with the relatively small cohort size - could have prevented small risks to be detected.
October 9th, 2008. Health Effects of Nanoparticles and Nanomaterials (III)
Recent reports suggest that carbon nanotubes, fiber-shaped biopersistent nanoparticles, resemble asbestos in the pathogenesis of granuloma and mesothelioma. As such we summarize health effects of environmental and manufactured nanoparticles in the literature so far including our studies, in this report.
October 8th, 2008. Mesothelioma and Environmental Exposure: A Newly Developed Animal Model for Fiber Exposure
Following the 12-month exposure, lack of mesothelioma induction was detected in all groups. Results suggest that the mechanism of mesothelioma formation is not a consequence of peritoneal physical exposure to the fibers.
October 8th, 2008. Pooled analysis of NAT2 genotypes as risk factors for asbestos-related malignant mesothelioma
04). These results suggest that NAT2 polymorphisms do not exert a strong effect on individual susceptibility to MM.
October 7th, 2008. Functional inactivation of NF2/merlin in human mesothelioma
Our results support the hypothesis that the disruption of NF2 signalling is essential for the development of human mesothelioma. In tumors where no NF2 truncation can be detected, NF2 is rendered inactive by phosphorylation of Ser 518 and this can be explained at least in part by an increased expression of CPI-17.
September 30th, 2008. Acrylamide Carcinogenicity
The mode of action remains unclear for acrylamide-induced rodent carcinogenicity, but support for a genotoxic mechanism based on in vitro and in vivo DNA reactivity assays cannot be ruled out. In addition, the pattern of tumor formation in the rat following chronic exposure supports a genotoxic mode of action but also suggests a potential role of endocrine modification.
September 27th, 2008. Treatment of peritoneal mesothelioma in pediatric patients
Treatment was well tolerated, and three of these patients have achieved long-term survival. The fathers of three of the patients worked in the construction industry and may have been the source of indirect asbestos exposure.
Posted in Case Study, Causation, Cisplatin (Platinol ®), Determining Efficacy, Full Archive, Occupational Asbestos Exposure, Peritoneal (Abdominal Mesothelioma), Survival, Treatment, Type of Assessment:, Type of Mesothelioma: | 2 Comments »
September 24th, 2008. The relationship between malignant mesothelioma and an asbestos cement plant environmental risk: a spatial case–control study in the city of Bari (Italy)
Conclusion: Evidence of an association between mesothelioma risk and EAE is highlighted. The role played by the RMR in increasing the public health local authorities awareness is stressed. Keywords Asbestos-cement plant - Environmental-neighborhood exposure - Mesothelioma register - Spatial case–control study - Public health - Italy
September 23rd, 2008. Predicted mortality from malignant mesothelioma among women exposed to blue asbestos at Wittenoom, Western Australia
Conclusion: The high toll from mesothelioma in this cohort of women and girls will continue well into the future.
September 17th, 2008. Orally Ingested Chrysotile Asbestos Affects Rat Lungs and Pleura
The authors observed mesothelial proliferation in all group B rats at the end of 12 months. Ingested asbestos traveled from the gastrointestinal system to the lungs, likely via a lymphohematological route, leading to mesothelial proliferation, which may lead to malignancies.
September 17th, 2008. Raw single-wall carbon nanotubes induce oxidative stress and activate MAPKs, AP-1, NF-kappaB, and Akt in normal and malignant human mesothelial cells
Conclusions: The cellular and molecular findings reported here do suggest that SWCNTs can cause potentially adverse cellular responses in mesothelial cells through activation of molecular signaling associated with oxidative stress, which is of sufficient significance to warrant in vivo animal exposure studies.
September 13th, 2008. Pathogenesis of malignant pleural mesothelioma and the role of environmental and genetic factors
Conclusion: Many risk factors for MPM development have been recognized including environmental exposures, genetic susceptibility, viral contamination, and radiation. In this review, we discuss the current molecular and genetic contributors to MPM pathogenesis and the risk factors associated with these carcinogenic processes.
September 9th, 2008. Characteristics and modifying factors of asbestos-induced oxidative DNA damage
p. chrysotile, our data suggest that asbestos-associated catalytic iron, whether constitutional or induced by other mechanisms, plays an important role in asbestos-induced carcinogenesis and that chemoprevention may be possible through targeting the catalytic iron.
September 9th, 2008. Clinical consequences of asbestos-related diffuse pleural thickening: A review
It causes a restrictive defect on lung function and may rarely result in respiratory failure and death. Treatment is primarily supportive.
Posted in CT or CAT scan, Causation, Diagnosis & Differentiation, Environmental Asbestos Exposure, Full Archive, Occupational Asbestos Exposure, PET Scan, Pleural Effusion, Symptoms & Symptom Management, Treatment, Type of Assessment: | No Comments »
September 5th, 2008. Asbestos Surveillance Program Aachen (ASPA): initial results from baseline screening for lung cancer in asbestos-exposed high-risk individuals using low-dose multidetector-row CT
28% (8/187) at baseline screening with an additional large number of indeterminate pulmonary nodules. Low-dose MDCT proved to be feasible in this highly selected population.
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