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Journal Articles on Mesothelioma: Cancer Information for Patients and Families

Archive for January, 2011

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January 7th, 2011. FDG PET/CT patterns of treatment failure of malignant pleural mesothelioma: relationship to histologic type, treatment algorithm, and survival

Conclusion: FDG PET/CT is an accurate modality to diagnose and to estimate the extent of locoregional and distant MPM recurrence, and it carries independent prognostic value. Once the disease recurs, survival outcomes seem to be independent of histologic type and highly dependent on the intensity of lesion uptake and on the pattern of metabolically active disease in FDG PET/CT. Our observations should be considered limited to patients treated surgically with or without perioperative therapies and should not be extrapolated to those unresectable cases treated with chemotherapy alone. Keywords FDG, FDG PET/CT, Mesothelioma, Lung cancer, Response to treatment, Recurrence, Survival
Posted in CT or CAT scan, Diagnosis & Differentiation, Full Archive, PET Scan, Pleural, Survival, Type of Assessment:, Type of Mesothelioma: | No Comments »

January 7th, 2011. The expression of CXCR4, CXCL12 and CXCR7 in malignant pleural mesothelioma

In conclusion, CXCR4 and CXCL12 are highly expressed in most mesothelioma cell lines and tumour tissues, suggesting that CXCR4 and CXCL12 may be used as biomarkers for patients with mesothelioma. The CXCL12–CXCR4 interaction may be a potential therapeutic target for mesothelioma.
Posted in Full Archive, New & Novel, Treatment, Type of Assessment: | No Comments »

January 6th, 2011. Establishment of a cell line from Japanese patient useful to generate an in vivo model for malignant pleural mesothelioma

These results indicate that MM56 cells can behave in a manner characteristic of human malignant pleural mesothelioma in the thoracic cavity of BALB/c-nude mice. The in vivo model using MM56 cells may be useful to study the biological behavior of malignant pleural mesothelioma and develop its diagnostic and therapeutic strategies.
Posted in Diagnosis & Differentiation, Full Archive, Pleural, Pleural Effusion, Symptoms & Symptom Management, Treatment, Type of Assessment:, Type of Mesothelioma: | No Comments »

January 6th, 2011. Summary of Presentations from the 46th Annual Meeting of the American Society of Clinical Oncology (2010) Focus on Tumor Biology and Biomarkers Related to Lung Cancer

Novel genetic mutations were identified in pleural mesothelioma using array-based technologies. Several studies on the development and testing of new molecular diagnostic tests to detect epidermal growth factor receptor tyrosine kinase mutations and EML4-ALK (Echinoderm Microtubule-associated Protein like 4 Anaplastic Lymphoma Receptor Tyrosine Kinase) fusion gene were presented as well.
Posted in EGFR, Full Archive, Kinase Inhibitors, New & Novel, Treatment, Type of Assessment: | No Comments »

January 5th, 2011. Pleural Mesothelioma in New Caledonia: Associations with Environmental Risk Factors

Conclusions: Presence of serpentinite on roads is a major environmental risk factor for mesothelioma in New Caledonia.
Posted in Causation, Environmental Asbestos Exposure, Full Archive, Type of Assessment: | No Comments »

January 5th, 2011. Pleural mesothelioma in paraoccupational, environmental and occupational patients exposed to asbestos

Conclusions: There is a low incidence of malignant mesothelioma in our population. Male was the predominant group. Occupational and paraoccupational exposure predominated in patients.
Posted in Causation, Full Archive, Occupational Asbestos Exposure, Type of Assessment: | No Comments »

January 5th, 2011. Antiangiogenic therapies for malignant pleural mesothelioma

Further understanding of the functional characteristics of tumor angiogenesis may be essential to improve targeting therapies in MPM. In this review, we introduce current status of clinical strategies and novel therapeutic approaches against angiogenesis in MPM.
Posted in Angiogenesis, Full Archive, Kinase Inhibitors, New & Novel, Pleural, Treatment, Type of Assessment:, Type of Mesothelioma: | No Comments »
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