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Journal Articles on Mesothelioma: Cancer Information for Patients and Families

Archive for August, 2008

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August 30th, 2008. YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation

Future studies of transcriptional targets of YAP1 in MPMs may shed light on the molecular mechanisms of MPM development and lead to new therapeutic strategies. Abbreviations: BAC, bacterial artificial chromosome; CGH, comprehensive genomic hybridization; EGFP, enhanced green fluorescent protein; GST, glutathione S-transferase; MPM, malignant pleural mesothelioma; NF2, neurofibromatosis type 2; NHERF1, Na(+)/H(+) exchanger regulatory factor 1; PCR, polymerase chain reaction; RNAi, RNA interference; SDS, sodium dodecyl sulfate; sh, short hairpin.
Posted in Full Archive, Gene Therapy, New & Novel, Treatment, Type of Assessment: | No Comments »

August 30th, 2008. Technical aspects of cytoreductive surgery

The panel also agreed that in the closed technique for HIPEC administration the intestinal anastomoses should be fashioned after completion of the perfusion. Finally when considering the place for protective ostomies the experts voted for a flexible approach allowing the surgeon to exercise discretion for individual patients.
Posted in Determining Efficacy, Full Archive, Peritoneal (Abdominal Mesothelioma), Surgery, Treatment, Tumor Debulking, Type of Assessment:, Type of Mesothelioma: | No Comments »

August 30th, 2008. The Fifth International Workshop on Peritoneal Surface Malignancy (Milan, Italy, December 4-6, 2006): methodology of disease-specific consensus

4%). The general treatment guidelines and future investigational perspectives were defined.
Posted in Full Archive, General, Peritoneal (Abdominal Mesothelioma), Type of Assessment:, Type of Mesothelioma: | No Comments »

August 30th, 2008. Consensus statement on peritoneal mesothelioma

The results were presented for further debate during a dedicated session of the Workshop. The general treatment guidelines and future investigational perspectives were defined.
Posted in Chemotherapy, Determining Efficacy, Full Archive, Intraperitoneal Chemotherapy, Surgery, Treatment, Tumor Debulking, Type of Assessment: | No Comments »

August 30th, 2008. Occupational exposure to asbestos and mortality among asbestos removal workers: a Poisson regression analysis

This study is a first step in assessing long-term mortality of asbestos removal workers in relation to working practices and asbestos exposure. Further follow-up will allow the impact of recent regulations to be assessed.
Posted in Causation, Epidemiological, Full Archive, Occupational Asbestos Exposure, Type of Assessment: | No Comments »

August 30th, 2008. Link]

Goudar RK.

Department of Medicine, Division of Hematology, Medical Oncology and Cellular Therapy, Duke University Medical Center, Durham, NC, USA.

Abstract

Malignant pleural mesothelioma is a resistant form of lung cancer, and its incidence continues to rise in Europe and Australia. Until recently, chemotherapy had not been shown to be effective in the treatment of this slowly progressive disease. In 2004, the combination of pemetrexed and cisplatin was shown to induce high response rates in MPM. This article reviews the published literature describing the development and testing of this therapeutic combination in mesothelioma, and examines in detail the key phase III clinical trial that led to the approval of pemetrexed by the US FDA. Ongoing research will further define the role of pemetrexed plus cisplatin in the treatment of MPM.

Keywords: malignant pleural mesothelioma, mesothelioma, pemetrexed, cisplatin

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Therapeutics and Clinical Risk Management. 2008 Feb;4(1):205-11. [Link]

Goudar RK.

Department of Medicine, Division of Hematology, Medical Oncology and Cellular Therapy, Duke University Medical Center, Durham, NC, USA.

Abstract

Malignant pleural mesothelioma is a resistant form of lung cancer, and its incidence continues to rise in Europe and Australia. Until recently, chemotherapy had not been shown to be effective in the treatment of this slowly progressive disease. In 2004, the combination of pemetrexed and cisplatin was shown to induce high response rates in MPM. This article reviews the published literature describing the development and testing of this therapeutic combination in mesothelioma, and examines in detail the key phase III clinical trial that led to the approval of pemetrexed by the US FDA. Ongoing research will further define the role of pemetrexed plus cisplatin in the treatment of MPM.

Keywords: malignant pleural mesothelioma, mesothelioma, pemetrexed, cisplatin

This article reviews the published literature describing the development and testing of this therapeutic combination in mesothelioma, and examines in detail the key phase III clinical trial that led to the approval of pemetrexed by the US FDA. Ongoing research will further define the role of pemetrexed plus cisplatin in the treatment of MPM.
Posted in Chemotherapy, Cisplatin (Platinol ®), Full Archive, Pemetrexed (Alimta), Pleural, Treatment, Type of Assessment:, Type of Mesothelioma: | No Comments »

August 30th, 2008. Metastatic appendiceal mucinous adenocarcinoma to well-differentiated diffuse mesothelioma of the peritoneal cavity: a mimicker of florid mesothelial hyperplasia in association with neoplasms

Although commonly associated with atypical/ florid mesothelial hyperplasia, a carcinoma can rarely metastasize to a well-differentiated mesothelioma, which can pose significant diagnostic difficulties because it can mimic a reactive process. This unusual case report expands the spectrum of mesothelial proliferation in conjunction with a malignant neoplasm and serves to remind pathologists that such a concomitant occurrence exists.
Posted in Case Study, Diagnosis & Differentiation, Diffuse mesothelioma, Full Archive, Peritoneal (Abdominal Mesothelioma), Type of Assessment:, laparoscopy | No Comments »

August 30th, 2008. Novel Oncolytic Agent GLV-1h68 Is Effective Against Malignant Pleural Mesothelioma

GLV-1h68 was successfully used to treat MPM in vitro and in an orthotopic model (in vivo). These promising results warrant clinical investigation of GLV-1h68 as a novel agent in the treatment of MPM.
Posted in Full Archive, Gene Therapy, New & Novel, Treatment, Type of Assessment: | No Comments »

August 30th, 2008. Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2

These results indicate that LPA is a critical factor on proliferation though LPA1, and on motility though LPA2 in MPM cells. Therefore, LPA and LPA receptors, LPA2 as well as LPA1, represent potential therapeutic targets for patients with MPM.
Posted in Full Archive, Immune-based Therapies, New & Novel, Treatment, Type of Assessment: | No Comments »

August 30th, 2008. Alterations in manganese, copper, and zinc contents, and intracellular status of the metal-containing superoxide dismutase in human mesothelioma cells

Conclusions: In comparison with MeT-5A human mesothelial cells, some human mesothelioma cells had significantly higher amounts of Mn or Cu and one mesothelioma cell had a significantly higher amount of Zn. Interestingly, all mesothelioma cells overexpressed Mn-SOD compared with MeT-5A, and the cells whose Mn-SOD activity was increased contained higher amounts of Mn. It seemed that intracellular Mn content was positively correlated with Mn-SOD, suggesting that the intracellular Mn level is associated with Mn-SOD activity. These biochemical signatures could be potential disease-related markers of mesothelioma.
Posted in Diagnosis & Differentiation, Full Archive, Serum Marker/Blood Test, Type of Assessment: | No Comments »

August 23rd, 2008. Asbestos clinics and asbestos health examinations–findings from a questionnaire survey of implementing organizations

The organizations we surveyed have important roles to play. Although resources are limited, effective diagnosis and treatment are essential, and a system assisting organizations to make accurate and efficient identification of asbestos exposure hazards is imperative.
Posted in Causation, Environmental Asbestos Exposure, Epidemiological, Full Archive, Type of Assessment: | No Comments »

August 22nd, 2008. Successful palliation of malignant ascites from peritoneal mesothelioma by laparoscopic intraperitoneal hyperthermic chemotherapy

LHIPEC could be a good therapeutic option to palliate malignant ascites from mesothelioma in cases not eligible for a radical treatment. Further studies are needed to standardize dosage and perfusion parameters.
Posted in Chemotherapy, Determining Efficacy, Doxorubicin, Full Archive, Intraperitoneal Chemotherapy, Treatment, Type of Assessment: | No Comments »

August 19th, 2008. Primary malignant mesothelioma developed in liver

A local recurrence was noted 15 months after surgery, which was treated by radiofrequency ablation. At 23 months after initial surgery, locally recurrent masses with direct invasion of the diaphragm and a solitary intrahepatic metastasis were noted, which was treated by partial excision of the diaphragm with intraoperative RFA after transarterial chemoembolization.
Posted in Case Study, Diagnosis & Differentiation, Epithelioid, Full Archive, Immunohistochemistry or IHC, Radiofrequency Ablation, Surgery, Treatment, Type of Assessment:, Type of Mesothelioma: | 1 Comment »

August 19th, 2008. Rectus abdominis muscle resection for abdominal wall recurrence of mucinous adenocarcinoma or peritoneal mesothelioma

Conclusions: No patients required reoperation for abdominal wall hernia and mesh repair was not used in any of these patients. Disease control within the abdominal wall has been excellent.
Posted in Diagnosis & Differentiation, Full Archive, Peritoneal (Abdominal Mesothelioma), Type of Assessment:, Type of Mesothelioma:, laparoscopy | No Comments »

August 19th, 2008. Mesothelioma Epidemiology, Carcinogenesis, and Pathogenesis

An exciting new development comes from the discovery that genetic susceptibility to mineral fiber carcinogenesis plays a critical role in the incidence of this cancer in certain families. It is hoped that the identification of this putative mesothelioma gene will lead to novel mechanistically driven preventive and therapeutic approaches.
Posted in Causation, Epidemiological, Full Archive, General, Occupational Asbestos Exposure, SV40, Type of Assessment: | No Comments »

August 14th, 2008. National Mesothelioma Virtual Bank: a standard based biospecimen and clinical data resource to enhance translational research

Conclusion: The NMVB currently has over 600 annotated cases available for researchers that include paraffin embedded tissues, tissue microarrays, serum and genomic DNA. The NMVB is a virtual biospecimen registry with robust translational biomedical informatics support to facilitate basic science, clinical, and translational research. Furthermore, it protects patient privacy by disclosing only de-identified datasets to assure that biospecimens can be made accessible to researchers.
Posted in Epidemiological, Full Archive, General, Type of Assessment: | No Comments »

August 14th, 2008. Soft tissue sarcoma metastatic to pleura

It is very difficult to distinguish them form sarcomatous malignant mesothelioma on histopathological features. We report a 57 year-old man who presented to us with left chest pain and progressive dyspnea and was diagnosed to have a pleural metastases of soft tissue sarcoma by thoracoscopic biopsy.
Posted in Diagnosis & Differentiation, Full Archive, Pleural, Pleural Biopsy, Sarcomatoid, Type of Assessment:, Type of Mesothelioma:, thoracoscopy | No Comments »

August 14th, 2008. Full-thickness pleural biopsy using an Insulation-tipped Diathermic knife in a patient with malignant pleural mesothelioma

Pathology revealed extensive fibrosis and epithelial mesothelioma by the specimen. This biopsy technique using IT knife through semiflexible thoracoscopy enabled to obtain a full-thickness pleura It is thought to be useful for the diagnosis of malignant pleural mesothelioma (MPM) in which standard forceps are difficult to grasp.
Posted in Case Study, Diagnosis & Differentiation, Full Archive, Pleural Biopsy, Type of Assessment:, thoracoscopy | No Comments »

August 14th, 2008. Enhanced antitumor therapy by inhibition of p21waf1 in human malignant mesothelioma

Conclusions: These results indicated that p21 might play an important role in chemosensitivity to anticancer agents, and the suppression of its expression might be a potential therapeutic target for MPM.
Posted in Full Archive, Immune-based Therapies, Kinase Inhibitors, New & Novel, Treatment, Type of Assessment: | No Comments »

August 14th, 2008. Acute generalized exanthematous pustulosis after pemetrexed, and recurrence after re-introduction

Pemetrexed is an antifolate drug, approved for treatment of metastatic non-small-cell lung cancer (NSCLC) and malignant pleural mesothelioma (MPM). We present a case of AGEP caused by pemetrexed, and a recurrence of this eruption after re-introduction of pemetrexed despite use of corticosteroids.
Posted in Chemotherapy, Full Archive, Pemetrexed (Alimta), Treatment, Type of Assessment: | No Comments »
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