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Journal Articles on Mesothelioma: Cancer Information for Patients and Families

Archive for February, 2008

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February 16th, 2008. The Lombardy Mesothelioma Register, Regional Operating Centre (ROC) of National Mesothelioma Register: organizative aspects

e. sinonasal cancers).
Posted in Epidemiological, Full Archive, General, Type of Assessment: | No Comments »

February 13th, 2008. Phase-contrast microscopy studies of early Cisplatin-induced morphological changes of malignant mesothelioma cells and the correspondence to induced apoptosis

Increased membrane protrusions were identified with PCM and SEM, but these were not consistent with the induction of apoptosis. The authors concluded that very early morphological changes can be determined with PCM in MPM, but they did not convincingly correspond to apoptosis induction.
Posted in Chemotherapy, Cisplatin (Platinol ®), Determining Efficacy, Full Archive, Treatment, Type of Assessment: | No Comments »

February 11th, 2008. Expression of mesothelin as a potential diagnostic marker in mesothelioma

None of the sarcomatoid mesotheliomas exhibited positivity for this marker, nor was any reactivity seen in the spindle cell component of the biphasic mesotheliomas. These findings indicate that, in some instances, mesothelin immunostaining can assist in the diagnosis of mesothelioma.
Posted in Biphasic or Mixed, Diagnosis & Differentiation, Epithelioid, Full Archive, Immunohistochemistry or IHC, Type of Assessment:, Type of Mesothelioma: | No Comments »

February 11th, 2008. Intensity-Modulated Radiotherapy for Resected Mesothelioma: The Duke Experience

Conclusions: With limited follow-up, 45-Gy IMRT provides reasonable local control for mesothelioma after extrapleural pneumonectomy. However, treatment-related pulmonary toxicity remains a significant concern. Care should be taken to minimize the dose to the remaining lung to achieve an acceptable therapeutic ratio.
Posted in Determining Efficacy, Extrapleural Pneumonectomy (EPP), Full Archive, IMRT, Radiation, Surgery, Treatment, Type of Assessment: | No Comments »

February 11th, 2008. Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis

Future studies involving the design of nAChR antagonists with improved selectivity might identify novel strategies for the treatment of tobacco-related cancers. Here we review the cellular roles of non-neuronal nAChRs, including regulation of cell proliferation, angiogenesis, apoptosis, migration, invasion and secretion.
Posted in Angiogenesis, Full Archive, New & Novel, Pleural, Treatment, Type of Assessment:, Type of Mesothelioma: | No Comments »

February 8th, 2008. Ensemble methods for classification of patients for personalized medicine with high-dimensional data

Conclusion: The statistical classification method for individualized treatment of diseases developed in this study is expected to play a critical role in developing safer and more effective therapies that replace one-size-fits-all drugs with treatments that focus on specific patient needs.
Posted in Diagnosis & Differentiation, Full Archive, Gene Therapy, New & Novel, Treatment, Type of Assessment: | No Comments »

February 7th, 2008. PTEN expression is a strong predictor of survival in mesothelioma patients

Conclusion: PTEN is an independent prognostic biomarker in mesothelioma patients. The frequent loss of expression of the tumour suppressor gene PTEN suggests involvement of the PI3K-AKT/protein kinase B (PKB) pathway in MPMs, which may be relevant for future mesothelioma treatment.
Posted in Diagnosis & Differentiation, Full Archive, Gene Therapy, Immunohistochemistry or IHC, Pleural, Serum Marker/Blood Test, Survival, Treatment, Type of Assessment:, Type of Mesothelioma: | No Comments »

February 2nd, 2008. Cost-effectiveness of pemetrexed plus cisplatin: malignant pleural mesothelioma treatment in UK clinical practice

Conclusions: Pemetrexed/cisplatin demonstrated acceptable cost-effectiveness when compared with cisplatin monotherapy and alternative treatments commonly used in UK clinical practice.
Posted in Chemotherapy, Cisplatin (Platinol ®), Determining Efficacy, Full Archive, Pemetrexed (Alimta), Pleural, Treatment, Type of Assessment:, Type of Mesothelioma:, Vinorelbine, mitomycin-C | No Comments »
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