Archive for December, 2007
December 17th, 2007. Aggressive Surgical Management of Peritoneal Carcinomatosis With Low Mortality in a High-Volume Tertiary Cancer Center
Conclusions: In a high-volume center with extensive experience treating peritoneal malignancies, perioperative mortality can be lowered to nearly zero, although morbidity remains high. CS-HIPEC procedures should be studied further in a controlled manner to help define their important role in the care of patients with PC.
Posted in Chemotherapy, Determining Efficacy, Full Archive, Intraperitoneal Chemotherapy, Peritoneal (Abdominal Mesothelioma), Surgery, Survival, Treatment, Tumor Debulking, Type of Assessment:, Type of Mesothelioma: | No Comments »
December 13th, 2007. Fluoro-edenite fibres induce lung cell apoptosis: an in vivo study
The integrity of alveolar epithelium and alveolar apoptosis are critical determinants in the pathways that initiate fibrogenesis in the lung and fibroblastic foci are usually found close to abnormal or denuded alveolar epithelium. Our results are consistent with the hypothesis that apoptosis is an important mechanism for removing cells with irreparable fluoro-edenite-induced genetic changes that predispose them to a neoplastic evolution.
December 12th, 2007. Mesothelioma incidence around Goor, The Netherlands, and far beyond, the asbestos drama unfolds
The WHO and the International Labour Office are collaborating towards the elimination of asbestos-related diseases worldwide. More awareness is needed in order to prevent similar tragedies occurring from other side effects of work.
December 12th, 2007. Environmental exposure to asbestos in the area around Goor has been established as the cause of pleural mesothelioma in women
Conclusion: The environmental pollution to asbestos waste materials in the area around Goor was the main cause of the strongly increased incidence of pleural mesothelioma among women in this area. Taking into account an equal risk among men, the consequences of asbestos exposure in the area around Goor in the next 25 years are likely to result in 2 cases of pleural mesothelioma each year.
December 8th, 2007. Endoscopic ultrasound-guided fine needle aspiration is useful for nodal staging in patients with pleural mesothelioma
EUS-FNA is a safe N2 node staging technique in patients with mesothelioma. A positive N2 lymph node by EUS-FNA may be a contraindication to definitive surgery in patients with malignant mesothelioma.
December 8th, 2007. Utility of WT-1, p63, MOC31, mesothelin, and cytokeratin (K903 and CK5/6) immunostains in differentiating adenocarcinoma, squamous cell carcinoma, and malignant mesothelioma in effusions
A negative stain with MOC31 can exclude lung ADC. Mesothelin, on the other hand, is not useful in the differential diagnosis of ADC, SCC, and MM.
December 7th, 2007. The productive district of textile asbestos in the Lower Iseo Lake area
Finally we shortly describe the work of the four other factories and in more detail that of the "Manifattura Sebina srl" is mentioned herein because, although this is a "typical" textile mill and exclusively manufacturing cotton products, a considerable number of cases of mesothelioma has been detected among its workforce. This has been attributed to the presence of asbestos insulated piping, to maintenance and replacement interventions on looms brake pads, and above all to the nearly 50 asbestos blankets that were employed in the weekly fire-fighting exercises, and usually leaned against the walls of departments, with no protection whatsoever.
December 7th, 2007. The epidemiologic surveillance of malignant mesothelioma in the Lower Iseo Lake area
8 x 100,000, 1977-2005) is the highest never estimate in Italy. The epidemiological surveillance of the mesothelioma appear essential to identify cases unreported and allow the collection of information useful to understand clearly the asbestos exposure effects on health's workers and to estimate the tumour incidence in the population.
December 7th, 2007. Epidemiological surveillance of malignant mesothelioma cases in Italy: incidence and asbestos exposure figures by the Italian mesothelioma registry (ReNaM)
In addition to the conventional sectors (shipbuilding, railways repair and demolition, asbestos-cement production), also textile, building, transport, chemical and glass industries, petroleum and sugar refineries, electricity production and distribution plants are getting involved. Despite the absence of some regions completing the national coverage and the non homogeneity in collecting and coding data, the epidemiological surveillance of malignant mesothelioma carried out by ReNaM is an important tool for the scientific knowledge and the prevention of asbestos-related diseases.
December 7th, 2007. Asbestos exposure in the non-asbestos textile industry: the experience of the Lombardy Mesothelioma Registry
The system devised by the Lombardy Registry had brought to light an occupational hazard in a professional area previously never believed as a source of asbestos exposure. In consideration of the described experience, both environmental and clinical, it seems reasonable to consider the non-asbestos-textile as a new department at risk for asbestos exposure.
December 7th, 2007. Mesothelioma incidence decreases parallel to asbestos exposure decrement or interruption: a confirmation of a dose-response relationship, with implications in public health
This is supported also by the fact that even the most biopersistent asbestos fibres are eliminated from the lungs. Indeed, a slow but effective reduction of risk has been demonstrated in the cohort of Wittenoom workers in Australia, previously exposed to crocidolite.
December 7th, 2007. Asbestos: a long lasting tragedy. Useful considerations for a historical reconstruction of the most remarkable facts
These legal actions will carry to bankruptcy all the asbestos companies and later to the ban of asbestos. The judicial debates will also uncover "confidential" information useful to better reconstruct the epic, to formulate more dispassionate historical judgments and to allow everyone on answering to more complex questions and more important than how much generally it was previously believed; all this should happen contextualizing the ages in which the scientific acquaintances on the effects of asbestos have been published and disproving prejudgments, able to affect some conclusions of the past.
December 7th, 2007. Renal cell carcinoma with malignant pleural mesothelioma after asbestos exposure: a case report
The incidence is rising in industrialized countries, with the peak expected in the year 2020. However, renal cell carcinoma with malignant pleural mesothelioma is very rare and this is the 2nd case in the Japanese literature.
Posted in Case Study, Causation, Chemotherapy, CT or CAT scan, Diagnosis & Differentiation, Epidemiological, Extrapleural Pneumonectomy (EPP), Full Archive, Occupational Asbestos Exposure, Pleural, Pleural Effusion, Radiation, Surgery, Symptoms & Symptom Management, Treatment, Trimodality Therapy, Type of Assessment:, Type of Mesothelioma: | No Comments »
December 7th, 2007. Swedish Experience with Peritonectomy and HIPEC. HIPEC in Peritoneal Carcinomatosis
Conclusion: Postoperative morbidity is dependent mainly on a tumor type; however, the chemotherapeutic agent used might also influence morbidity. Survival is determined by optimal cytoreduction and tumor type. Irrespective of age, patients with good performance status benefit from this treatment.
December 7th, 2007. CD200: A putative therapeutic target in cancer
Moreover, we show that CD200 expression is associated with tumor progression in various cancers. Taken together, these data suggest that CD200 is a potential therapeutic target and prognostic factor for a large array of malignancies.
December 7th, 2007. Current state and future directions of pleural mesothelioma imaging
This communication conveys the pitfalls and potential of pleural mesothelioma imaging based on work presented at the Conference. From diagnosis to response, PET/CT to molecular bioprobes, volumetric analysis to computerized tumor assessment, imaging promises to provide valuable insight for patients with mesothelioma and the physicians who treat them.
December 6th, 2007. A genetic mouse model for metastatic lung cancer with gender differences in survival
Additionally, the presence of both mutations induced pleural mesotheliomas in 23% of these mice. This mouse model recapitulates the metastatic nature of human lung cancer and will be invaluable to further probe the molecular basis of metastatic lung cancer and for translational studies.
December 6th, 2007. Pseudomesotheliomatous adenocarcinoma of the lung with synchronous gastric and esophageal cancer
An immunohistochemical investigation is important when it is difficult to determine whether diffuse carcinomatous involvement of the pleura is secondary to metastasis, lung cancer, or mesothelioma. We herein report a very rare case of concomitant pseudomesotheliomatous adenocarcinoma, gastric cancer and esophageal cancer.
December 1st, 2007. Radical surgery for malignant pleural mesothelioma: results and prognosis
0019), but not gender, side, surgical procedure, were significant independent negative prognostic factors. Although P/D appears to be acceptable in early stages, we encourage EPP, en bloc resection without entering the pleural cavity with intent for curability, which provides oncologically complete resection of all disease.
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