Journal Articles on Mesothelioma: March, 2007
March 16th, 2007. The role of radiotherapy in the treatment of malignant pleural mesothelioma
There is no role for radical radiotherapy alone, but the role of radiotherapy as part of multimodality therapy is discussed. There have been studies of intensity-modulated radiotherapy as part of multimodality therapy and this technique needs to be evaluated further.
March 16th, 2007. D2-40 and calretinin - a tissue microarray analysis of 341 malignant mesotheliomas with emphasis on sarcomatoid differentiation
66. These data indicate that a combination of calretinin and D2-40 will improve diagnostic accuracy for spindle cell lesions of the pleura, whereas almost all epithelioid mesotheliomas are identified by calretinin alone.
March 14th, 2007. Inmunohistochemistry and surgical approaches in solitary fibrous tumor of the pleura
In our opinion, VTC is a less invasive diagnostic and therapeutic approach than thoracotomy that provides an adequate approach for the resection of SFTP in selected patients. Because of the malignant potential of this tumor, long-term follow-up is mandatory.
March 14th, 2007. Expression of inhibitor-of-apoptosis protein family members in malignant mesothelioma
Nuclear survivin expression is reduced in effusions as compared with solid lesions concomitantly with reduced proliferation. XIAP is upregulated in mesothelioma effusions and peritoneal mesotheliomas, suggesting a prosurvival role in malignant mesothelioma cells, particularly at these anatomic sites.
March 14th, 2007. Ecological association between asbestos-related diseases and historical asbestos consumption: an international analysis
Interpretation: Within the constraints of an ecological study, clear and plausible associations were shown between deaths from the studied diseases and historical asbestos consumption, especially for all mesothelioma in both sexes and asbestosis in men. Our data strongly support the recommendation that all countries should move towards eliminating use of asbestos.
March 14th, 2007. Right extrapleural pneumonectomy for malignant mesothelioma via median sternotomy or thoracotomy? Short- and long-term results
Conclusions: Median sternotomy should be considered as an alternative approach to thoracotomy for right EPP.
March 14th, 2007. Local recurrence model of malignant pleural mesothelioma for investigation of intrapleural treatment
Conclusions: With this new recurrence model for investigation of malignant pleural mesothelioma in rats, we were able to investigate new intrapleural therapies after pneumonectomy. The intrapleural application of cisplatin-Vivostat® significantly reduced the extent of local recurrence.
March 14th, 2007. Clinico-pathological prognostic factors in malignant pleural mesothelioma
0349). EORTC prognostic scoring systems successfully stratify survival for a general hospital population, and TN might play an important role in poor outcome in malignant pleural mesothelioma.
March 14th, 2007. Stathmin is overexpressed in malignant mesothelioma
Conclusion: For the first time, stathmin was shown to be overexpressed in malignant mesothelioma. The overexpression of stathmin in mesothelioma may offer a potential therapeutic target and further studies are warranted.
March 14th, 2007. Erionite and asbestos differently cause transformation of human mesothelial cells
Our results reveal that erionite is able per se to turn HMC into transformed highly proliferating cells and disclose the carcinogenic properties of erionite, prompting for a careful evaluation of environmental exposure to these fibers. The genetic predisposition to the effect of erionite is a separate subject for investigation.
March 10th, 2007. Update on the molecular biology of malignant mesothelioma
Improvement in our understanding of the molecular biology of MM has identified promising new candidates for targeted treatments. In this review the key molecular signaling pathways, including vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), Wnt, and the cell cycle control genes p53, pRb, and bcl-2 that appear to play an important role in the pathogenesis of MM are explored.
March 9th, 2007. Blood tests for asbestos-related mesothelioma
Recently, serum markers for the diagnosis of mesothelioma have been reported as candidates. In this paper, we mini-reviewed the potential utility of ELISA systems as serum diagnostic markers for asbestos-related mesothelioma.
March 9th, 2007. Correlation of photodynamic activity and fluorescence signaling for free and pegylated mTHPC in mesothelioma xenografts
Conclusions: Fluorescence signaling measurement has the potential to predict the photodynamic activity for both mTHPC formulations in mesothelioma xenografts.
March 6th, 2007. Asbestos fibre dimensions and mesothelioma
The techniques for doing so now exist and can be applied. The ultrafine class of asbestos, forgotten for decades, must be the principal target for prevention programs and must be widely monitored in work and daily life settings.
March 6th, 2007. Case-control study between extrapleural pneumonectomy and radical pleurectomy/decortication for pathological N2 malignant pleural mesothelioma
Conclusions: Preservation of the lung during radical surgery for N2 MM does not compromise survival even in an older group population. We therefore now have ceased to perform EPP in cases of N2 disease and we make every effort to accurately stage patients with mediastinoscopy to identify them.
March 3rd, 2007. Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines
Conclusion: This study identifies several interesting targets for further investigation in relation to asbestos-associated diseases.
March 3rd, 2007. A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection
Thus, SM16 shows potent activity against established AB12 malignant mesothelioma tumors using an immune-mediated mechanism and can significantly prevent tumor recurrence after resection of bulky AB12 malignant mesothelioma tumors. These data suggest that ALK5 inhibitors, such as SM16, offer significant potential for the treatment of malignant mesothelioma and possibly other cancers.
March 3rd, 2007. Mild hyperthermia predisposes tumor cells to undergo apoptosis upon treatment with onconase
Although at 41 degrees C in absence of ONC the incidence of apoptosis was elevated compared to 37 degrees C the cytotoxicity of ONC was further enhanced and the overall pro-apoptotic effect was above the level of additive effects of ONC plus that of 41 degrees C-hyperthermia. While the mechanism of the observed enhancement of ONC cytotoxicity is currently under investigation, the findings suggest that a combination of ONC and mild hyperthermia should be explored to increase effectiveness of ONC in cancer treatment.
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