Journal Articles on Mesothelioma: March, 2007
March 31st, 2007. Non-occupational malignant pleural mesothelioma due to asbestos and non-asbestos fibres
Conclusion: It is likely that genetic predisposition and non-occupational exposure to low doses of asbestos and asbestos-like fibres may concur to the development of malignant mesothelioma. However, additional epidemiological and laboratory studies are needed to further understand the relationship between environmental exposure and individual susceptibility to this malignancy.
March 31st, 2007. Mesothelioma
Michele Carbone reviewed the most significant scientific and medical advances in understanding the pathogenesis of mesothelioma and some novel preventive and therapeutic approaches that are being developed. The public health and litigation issues, together with the economics surrounding mesothelioma research and therapy are also discussed.
March 31st, 2007. Asbestos-related diseases of the lungs and pleura: uses, trends and management over the last century.
In less-industrialised countries, data on disease are sparse, exposure generally high and rates may peak in the future. Management of asbestos-related disease in the workplace requires collaboration between workers and unions (responsible for monitoring workplace dust levels, to which they must have access) and companies (responsible for engineering controls), reinforced by appropriate government regulations and by community support.
March 31st, 2007. Inhibition of survivin and aurora B kinase sensitizes mesothelioma cells by enhancing mitotic arrests
Conclusion: Inhibition of survivin and Aurora B induces mitotic cell arrest in mesothelioma cells after irradiation. These two proteins may be potential therapeutic targets for the enhancement of radiotherapy in malignant pleural mesothelioma.
March 30th, 2007. Value of antimesothelioma HBME-1 in the diagnosis of inflammatory and malignant pleural effusions
33%) cases; the staining pattern in metastatic adenocarcinoma cells was thin membrane and focal cytoplasmic. HBME-1 has a moderate sensibility and specificity for mesothelial cells and can be used as part of a panel for differentiation of malignant and reactive mesothelial cells from adenocarcinoma in pleural effusions.
March 29th, 2007. Can serum inflammatory parameters estimate outcome of pleurodesis in mesothelioma?
Conclusion: Serum levels of inflammatory parameters (C-reactive protein and erythrocyte sedimentation rate) may be used to predict the success of pleurodesis in patients with malign mesothelioma who underwent thoracoscopic talc poudrage.
March 29th, 2007. Medical thoracoscopy in an Australian regional hospital
There was one fatality caused by pre-existing sepsis in a debilitated patient with disseminated carcinoma. Medical thoracoscopy is a simple, safe and cost-effective technique for diagnosing and treating pleural effusions and provides a useful service in the setting of a regional hospital.
March 28th, 2007. Retroperitoneal malignant schwannoma and peritoneal malignant mesothelioma: a case report
Singlemodality therapy of these tumors has shown poor results. Combined-modality approaches have shown some benefits, but further studies are required.
March 28th, 2007. A case of malignant mesothelioma in a rice-starch factory
Discussion: This case provides further confirmation of the importance of careful history taking among workers with mesothelioma to avoid failing to diagnose occupational disease. It also highlights the risk of asbestos exposure represented by recycling asbestos-contaminated sacks in both occupational and non-occupational settings.
March 27th, 2007. Assessment of asbestos in drinking water in Alexandria, Egypt
No fibers detected in regions, where the pipe distribution system was poly venyl pipe system or changed from A/C pipe to cast iron pipe system. The determination of asbestos fibers in drinking water of Alexandria should have particular concern because of the health hazards that might be associated with their presence.
March 27th, 2007. Taurolidine and povidone-iodine induce different types of cell death in malignant pleural mesothelioma
Taurolidine induces apoptosis and necrosis, activates p53 and sensitizes cells to cisplatin, whereas PVP-I inhibits cell growth via necrosis. Both agents are promising candidates for use in local treatment within multimodality concepts for MPM.
March 23rd, 2007. Asbestos-related lung disease
Because exposure to cigarette smoke increases the risk of developing lung cancer in patients with a history of asbestos exposure, smoking cessation is essential. Patients with asbestosis or lung cancer should receive influenza and pneumococcal vaccinations.
Posted in Benign, Causation, Diffuse mesothelioma, Epidemiological, Full Archive, General, Occupational Asbestos Exposure, Pleural, Treatment, Type of Assessment:, Type of Mesothelioma: | No Comments »
March 23rd, 2007. Cytological diagnosis of malignant mesothelioma–improvement by additional analysis of hyaluronic acid in pleural effusions
The addition of HA analysis to cytology, requiring all or some criteria of MM as positive, increased sensitivity for MM from 48 to 71–91%, whereas specificity only slightly decreased to 94–96%. We conclude that the combined cytological and HA analysis of pleural effusions had the potential to improve the diagnosis of MM.
March 21st, 2007. Immunohistochemical expression of osteopontin in epithelioid mesotheliomas and reactive mesothelial proliferations
Osteopontin expression is not restricted to malignant mesothelial proliferations, and immunohistochemical analysis for osteopontin is not helpful in determining reactive vs malignant mesothelial proliferations. The reported usefulness of osteopontin as a serum tumor marker for mesothelioma may be due to differences in the amount or character of secreted protein in malignant mesothelioma compared with reactive mesothelial proliferations.
March 21st, 2007. Infiltration of a mesothelioma by IFN-gamma-producing cells and tumor rejection after depletion of regulatory T cells
Depletion of CD25+ cells did not appear to modulate antitumor CTL activity on a per cell basis. Our data suggests that CD25+ Treg limit the accumulation of activated T cells producing IFN-γ in the tumor tissue and, to a lesser extent, activation and/or rate of mitosis of tumor-specific T cells in lymph nodes.
March 17th, 2007. Biphasic malignant mesothelioma cases with osseous differentiation and long survival: A review of the literature
Both patients survived 39 and 69 months, respectively. To our knowledge, these two cases with biphasic malignant mesothelioma and osseous differentiation with long survival are the first to be described from Central Anatolia.
March 17th, 2007. Sensitization of mesothelioma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by heat stress via the inhibition of the 3-phosphoinositide-dependent kinase 1/Akt pathway
Nonetheless, knockdown of Bid, the main intermediary molecule from the death receptor pathway to the mitochondria, inhibited the effect of heat stress, showing that mitochondrial amplification was required for potentiation by heat stress. In summary, these results support the novel concept that heat stress inhibits the Akt pathway by dissociating PDK-1 from its chaperone Hsp90, leading to potentiation of TRAIL-induced apoptosis in resistant malignant cells.
March 17th, 2007. Investigation of micronucleus frequencies in lymphocytes of inhabitants environmentally exposed to chrysotile asbestos
05). Although the detection of calcified pleural plaques found in the inhabitants has indicated environmental exposure to chrysotile asbestos, our results show that chrysotile asbestos was not an inducer of MN in subjects exposed to chrysotile asbestos.
March 16th, 2007. Emerging drugs for mesothelioma
At present, the regimen of cisplatin/pemetrexed is the medical treatment of choice. This review summarizes standard chemotherapy options and focusses on the molecular basis of the newest biologically targeted therapies to be implemented in the near future, in the management of MPM.
March 16th, 2007. Soluble mesothelin in effusions: a useful tool for the diagnosis of malignant mesothelioma
Conclusions: Measurement of mesothelin concentrations in the pleural and/or peritoneal effusion of patients may aid in the differential diagnosis of mesothelioma in patients presenting with effusions.
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