Conclusions: These data strongly suggest the significant usefulness of D2-40 and calretinin as positive markers, and of CEA and TTF-1 as negative markers, for pleural mesothelioma. The 4-antibody immunohistochemical panel showed high sensitivity and specificity with regard to differentiation of epithelioid mesothelioma from lung adenocarcinoma.
February 6th, 2007. Recommendations for the reporting of pleural mesothelioma
The ADASP realizes that specimens and practices vary, and it will not be possible to report these elements in every case. However, the ADASP hopes that pathologists will find these checklists to be useful in daily clinical practice, while facilitating compliance with the new COC requirements.
February 3rd, 2007. Clinical types of thoracic cancer. Pleural mesothelioma
Interest in this disease has increased for several reasons: the increase in incidence in the last twenty years, the heavy exposure of several groups of workers, claims for compensation for industrial disease and other medico-legal aspects, the question of environmental exposure with no threshold and the great media interest in the subject (3 million internet pages devoted to mesothelioma). Medical interest in this disease has evolved from almost total fatalism to a real interest in active management with acceptable surgery, new cytotoxic drugs and effective combinations, biological therapies, new modalities of radiotherapy and, above all, the development of multidisciplinary strategies to set up prospective randomised comparative trials which have been largely absent in this field.
February 3rd, 2007. Morphological aspects as prognostic factors in malignant mesothelioma: a study of 58 cases
Conclusion: The most useful immunohistochemical markers were was calretinin (for mesothelioma) and CEA (for adenocarcinoma). Immunohistochemical quantification of thrombomodulin facilitated the diagnosis of mesothelioma in patients testing positive for both calretinin and CEA. The most useful prognostic information was that provided by the routine histopathological analysis of the tumor type. It is of note that the combination of a mean age of 55 years and 30.5% immunohistochemical markers in nuclear components created a natural dividing point between patients in which survival was shorter than expected and those in which it was longer than expected. Therefore, histopathological analysis offers a powerful weapon with great potential to inform decisions regarding the use of adjuvant chemotherapy after surgical excision of a mesothelioma.
February 3rd, 2007. Malignant mesothelioma of the tunica vaginalis testis
The aggressiveness and poor prognosis of this tumor require radical surgery as the primary therapy. We describe the case of a 45 year old patient, in whom an epithelioid mesothelioma was incidentally detected after hydrocelectomy.
February 3rd, 2007. Malignant pleural mesothelioma with scalp, cerebellar, and finger metastases: a rare case
Histopathologic examination of the biopsy from the nodule on the scalp revealed a typical mixed type of MPM, with calretinin, vimentin and creatine 5/6 positivity. Distant metastases can be seen in MPM and a biopsy of metastatic regions can yield the diagnosis.
With polymerase chain reaction analysis, we determined the extent of the homozygous deletion regions of the p16INK4a/p14ARF locus in MPM cell lines, which indicated that the deletion regions varied among cell lines. Our results with array comparative genomic hybridization analysis provide new insights into the genetic background of MPM, and also give some clues to develop a new molecular target therapy for MPM.
February 3rd, 2007. Clinico-pathological features and somatic gene alterations in refractory ceramic fibre-induced murine mesothelioma reveal mineral fibre-induced mesothelioma identities
They suggest that Nf2 mutation is complementary of Ink4 or Trp53 mutations and show similar profile of gene alterations resulting from exposure to ceramic or asbestos fibres in Nf2+/- mice, also consistent with the one found in HMM. These somatic genetic changes define different pathways of mesothelial cell transformation.
February 3rd, 2007. Asbestos-related diseases
br Abstract This chapter presents a bibliographic review of asbestos-related diseases. The latest diagnostic, radiological, computed tomography and lung function aspects of benign pleural disease, asbestosis, occupational lung cancer and mesothelioma are discussed.
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