Journal Articles on Mesothelioma: February, 2006
February 28th, 2006. Occupational asbestos exposure: how to deal with suspected mesothelioma cases–the Dutch approach
Conclusions: Compared with other European countries, this approach, as determined by the IAV and Mesothelioma Group of the DTS, is an effective and rapid way to investigate claims of patients with a possible occupationally related malignant mesothelioma.
February 28th, 2006. Results of a Phase I trial of sorafenib (BAY 43-9006) in combination with doxorubicin in patients with refractory solid tumors
Conclusion: Sorafenib 400 mg bid plus doxorubicin 60 mg/m2 was well tolerated. The increased doxorubicin exposure with sorafenib 400 mg bid did not result in significantly increased toxicity; low patient numbers make the clinical significance of this unclear. These promising efficacy results justify further clinical investigation.
February 28th, 2006. alpha-Tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: Implication for sensitisation of resistant cancer cells to TRAIL apoptosis
Treatment with sub-lethal doses of α-TOS restored expression of DR4 and DR5. The ability of α-TOS to modulate expression of pro-apoptotic genes may play a role in sensitisation of tumour cells to immunological stimuli.
February 27th, 2006. Incidence and management of complications after neoadjuvant chemotherapy followed by extrapleural pneumonectomy for malignant pleural mesothelioma
Conclusions: Extrapleural pneumonectomy after neoadjuvant chemotherapy can be performed with mortality rates comparable to standard pneumonectomies. Complications are frequent but can be successfully managed; the EORTC-score seems to be a predictor for postoperative complications.
February 23rd, 2006. Immunohistochemical analysis of peritoneal mesothelioma and primary and secondary serous carcinoma of the peritoneum: antibodies to estrogen and progesterone receptors are useful
The other antibodies evaluated were insufficiently sensitive and/or specific to be diagnostically useful. In conjunction with calretinin and Ber-EP4, estrogen and progesterone receptors are useful discriminatory markers for distinguishing peritoneal mesothelioma from primary or metastatic serous carcinoma.
February 23rd, 2006. Cell proliferation rate and telomerase activity in the differential diagnosis between benign and malignant mesothelial proliferations
Conclusion: As a result, being cheap and simple methods, Ki-67 and hTERT immunohistochemistries can be used in differentiating malignant and benign mesothelial lesions in routine formalin-fixed, paraffin-embedded material.
February 20th, 2006. Multinucleation and pro-inflammatory cytokine release promoted by fibrous fluoro-edenite in lung epithelial A549 cells
Such cell changes occurred without interfering with the passage of the resulting multinucleated cells through the cell cycle and without condemning cells to death. Hence, in lung epithelial cells, fibrous fluoro-edenite behaved similarly to the unrelated asbestos type crocidolite, whose connection with severe inflammation and cancer of the lung is renowned.
February 14th, 2006. The French National Mesothelioma Surveillance Program
Conclusions: The NMSP is a large scale epidemiologic surveillance system with several original aspects, providing important information to improve the knowledge of malignant pleural mesothelioma, such as monitoring the evolution of its incidence, of high risk occupations and economic sectors, and improving pathology techniques.
February 14th, 2006. Imaging and therapy of malignant pleural mesothelioma using replication-competent herpes simplex viruses
Conclusion: These findings support the continued investigation of oncolytic HSV as potential therapy for patients with therapy-resistant MPM.
February 13th, 2006. Endovascular Therapy of Non-aneurysmatic Infrarenal Aortic Rupture
Discussion: This is the first report of endovascular repair of aortic rupture due to successful chemotherapy of a periaortic mesothelioma. Furthermore, this is the fourth case of successful stent-graft placement to treat non-aneurysmatic rupture of the infrarenal aorta. Minimally invasive endovascular therapy should become a standard treatment option for aortic rupture. Key words: aortic rupture - peritoneal mesothelioma - penetrating atherosclerotic ulcer - endovascular therapy - stent-graft system
February 10th, 2006. Video-assisted thoracoscopic surgery in diagnosis and treatment of pleuritis
Conclusions: Specificity of video-assisted thoracoscopic surgery in pleural diseases reaches 93.0%. Video-assisted thoracoscopic surgery is necessary even in cases of failed "blind" biopsies and possible in elderly patients. Video-assisted thoracoscopic surgery provides not only easy morphologic verification of pleural diseases but also performance of chemopleurodesis.
February 9th, 2006. Computed tomographic characterization of malignant peritoneal mesothelioma
Conclusions: Malignant peritoneal mesothelioma by CT evaluation predominates in tumor mass within the central and pelvic portions of the abdomen. Minimal, moderate, and extensive small bowel enlargements were seen in roughly one-third of the patients. With the use of the Z-score and interpretative small bowel findings a radiologic characterization of this disease for primary radiologic diagnosis is possible.
February 9th, 2006. Major carcinogenic pathways identified by gene expression analysis of peritoneal mesotheliomas following chemical treatment in F344 rats
Important carcinogenic pathways involved in RPM formation included insulin-like growth factor 1 (IGF-1), p38 MAPkinase, Wnt/β-catenin and integrin signaling pathways. This study demonstrated that mesotheliomas in rats exposed to o-NT- and BCA were similar to mesotheliomas in humans, at least at the cellular and molecular level.
February 9th, 2006. Value of Immunohistochemistry in Distinguishing Peritoneal Mesothelioma From Serous Carcinoma of the Ovary and Peritoneum: A Review and Update
The conclusion of this review indicates that the positive serous carcinoma markers, by and large, have a higher degree of sensitivity and specificity in assisting in discriminating between these malignancies than the positive mesothelioma markers. From a practical point of view, a combination of MOC-31 (or Ber-EP4), estrogen receptors, and calretinin immunostaining should allow a clear distinction to be made between epithelioid peritoneal mesotheliomas and serous carcinomas in most cases.
February 8th, 2006. Descriptive epidemiology of malignant mesothelioma
Conclusions: World production of asbestos has been declining dramatically in recent years, however increases have occurred in Asia. The decrease in asbestos use and a ban in several industrialized countries have proved effective in reducing the societal burden of MM.
February 8th, 2006. Nordic experience: expected decline in the incidence of mesotheliomas resulting from ceased exposure?
Conclusions: 25 years after interruption of asbestos exposure, the expected rapid decline in MM incidence is still lacking, which appears to agree with population-based selection phenomena, with survival of a large pool of asbestos-exposed subjects with minimal exposure.
February 8th, 2006. Malignant mesothelioma and the working environment: the viewpoint of the occupational physician
Conclusions: This experience highlights the multifaceted role of OP in active research and evaluation of MM cases, in the context of a multidisciplinary approach.
February 8th, 2006. Mesothelioma associated with environmental exposures
Conclusions: Both "natural"and industrial environmental asbestos or asbestiform fibre exposures increase potential risk for mesothelioma. Strategies of environmental reclamation and risk communication should be implemented in these areas.
February 8th, 2006. Epidemiologic surveillance for primary prevention of malignant mesothelioma: the Italian experience
Conclusions: Despite some ReNam's limitations, identification of MM cases and analysis of modality of exposure, with standardized criteria, are a fundamental tool for primary prevention of asbestos related diseases.
February 8th, 2006. SV40, genetic polymorphism and mesothelioma. pathological and epidemiological evidence
Discussion: Association of SV40 with human MM is suggested from laboratory observations but still lacks confirmation in well designed epidemiological studies. Other putative co-factors in MM occurrence are mutations in genes involved in repair of damage caused by asbestos, notably DNA-repair genes. Preliminary observations are available but epidemiological studies are needed to test this hypothesis.
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