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Journal Articles on Mesothelioma: Cancer Information for Patients and Families

Journal Articles on Mesothelioma: June, 2005

June 23rd, 2005. Residential Proximity to Naturally Occurring Asbestos and Mesothelioma Risk in California

Conclusions: These data support the hypothesis that residential proximity to NOA is significantly associated with increased risk of MM in California.
Posted in Causation, Environmental Asbestos Exposure, Full Archive, Type of Assessment: | No Comments »

June 15th, 2005. SV40-Dependent AKT Activity Drives Mesothelial Cell Transformation after Asbestos Exposure

Consequently, prolonged exposure to asbestos fibers progressively induces transformation of SV40-positive HMC. As a model of SV40/asbestos cocarcinogenesis, we propose that malignant mesothelioma originates from a subpopulation of transformed stem cells and that Akt signaling is a novel therapeutic target to overcome malignant mesothelioma resistance to conventional therapies.
Posted in Causation, Full Archive, New & Novel, SV40, Treatment, Type of Assessment: | No Comments »

June 15th, 2005. Validation of Genomics-Based Prognostic Tests in Malignant Pleural Mesothelioma

Conclusions: The data support the use of gene ratios in translating gene expression data into easily reproducible, statistically validated clinical tests for the prediction of outcome in MPM.
Posted in Diagnosis & Differentiation, Full Archive, Pleural, Type of Assessment:, Type of Mesothelioma: | No Comments »

June 13th, 2005. Limited efficacy of imatinib mesylate in malignant mesothelioma: A phase II trial

Side effects of the medication were mild and included edema, nausea, constipation and diarrhea. We conclude that further investigation with monotherapy imatinib in mesothelioma is not warranted.
Posted in Chemotherapy, Full Archive, Imatinib Mesylate (Gleevec/Glivec), Treatment, Type of Assessment: | No Comments »

June 13th, 2005. A phase II study evaluating the cisplatin and epirubicin combination in patients with unresectable malignant pleural mesothelioma

In conclusion, cisplatin plus epirubicin appears as an effective regimen in malignant mesothelioma, with a favourable toxicity profile. However, it does not demonstrate superior activity to other active regimens in this disease.
Posted in Chemotherapy, Cisplatin (Platinol ®), Epirubicin (Ellence), Full Archive, Pleural, Treatment, Type of Assessment:, Type of Mesothelioma: | No Comments »

June 8th, 2005. Assessment of asbestos exposure, mortality study, and health intervention in workers formerly exposed to asbestos in a small factory making drying machines for textile finishing and the paper mill industry in Pistoia, Italy

Conclusions: Further investigation is needed in order to identify unknown asbestos exposures in small metal engineering factories.
Posted in Causation, Epidemiological, Full Archive, Occupational Asbestos Exposure, Pleural, Type of Assessment:, Type of Mesothelioma: | No Comments »

June 8th, 2005. Asbestos risk in the textile industry: braking systems on machinery used until the 1990’s

Conclusions: the contribution of textile machinery to atmospheric pollution by asbestos fibres was significant and due both to the widespread use of brakes with asbestos-containing materials and to the continuous action on the machines of compressed air blowers. Asbestos pollution was certainly high in all the factories so that in the near future still further mesothelioma cases among ex-workers are to be expected.
Posted in Causation, Full Archive, Occupational Asbestos Exposure, Type of Assessment: | No Comments »

June 2nd, 2005. Integrated computed tomography-positron emission tomography in patients with potentially resectable malignant pleural mesothelioma: Staging implications

Conclusions: Integrated computed tomography-positron emission tomography increases the accuracy of malignant pleural mesothelioma staging and is important in determining the appropriate therapy in patients being considered for extrapleural pneumonectomy.
Posted in Extrapleural Pneumonectomy (EPP), Full Archive, Pleural, Staging, Surgery, Treatment, Type of Assessment:, Type of Mesothelioma: | No Comments »

June 1st, 2005. Mesothelial inclusion cysts (so-called benign cystic mesothelioma)–a clinicopathological analysis of six cases

One female failed to report for follow-up examinations. The report also presents the review of literature.
Posted in Benign, Full Archive, Type of Mesothelioma: | No Comments »

June 1st, 2005. Survival of malignant pleural mesothelioma cases in the Tuscan Mesothelioma Register, 1988-2000: a population-based study

There was no significant difference in survival between treated versus untreated patients. In conclusion, no advance in prognosis at the population level in the most recent period can be suggested on the basis of the data available to the Tuscan Malignant Mesothelioma Register.
Posted in Causation, Determining Efficacy, Full Archive, Pleural, Treatment, Type of Assessment:, Type of Mesothelioma: | No Comments »

June 1st, 2005. New agents in the management of advanced mesothelioma

With pemetrexed we now have a drug that is able to impact patient survival. Together with the newer drugs, rapidly emerging from the laboratory to be applied in the clinic, we have the hope of making further advances in the struggle against this disease.
Posted in Determining Efficacy, Full Archive, New & Novel, Pleural, Treatment, Type of Assessment:, Type of Mesothelioma: | No Comments »

June 1st, 2005. Advances in the diagnosis, evaluation, and management of malignant pleural mesothelioma

Patients with adequate performance status should be enrolled into clinical trials where possible. Over the past decade, significant advances have been made on several fronts that have improved the ability to diagnose a stage, define prognosis, and treat malignant pleural mesothelioma.
Posted in Determining Efficacy, Full Archive, New & Novel, Treatment, Type of Assessment: | No Comments »

June 1st, 2005. Cisplatin and Gemcitabine in Malignant Pleural Mesothelioma: A Phase II Study

In conclusion, gemcitabine-cisplatin combination seems to be moderately active in MPM. Furthermore, at this dose and schedule, the toxicity profile could be acceptable.
Posted in Chemotherapy, Cisplatin (Platinol ®), Full Archive, Gemcitabine (Gemzar), Pleural, Treatment, Type of Assessment:, Type of Mesothelioma: | No Comments »

June 1st, 2005. Identification of Novel Candidate Oncogenes and Tumor Suppressors in Malignant Pleural Mesothelioma Using Large-Scale Transcriptional Profiling

Finally, we used bioinformatics tools (ie, software) to create and explore complex physiological pathways. Combined, all of these data may advance our understanding of mesothelioma tumorigenesis, pathobiology, or both.
Posted in Full Archive, Pleural, Type of Mesothelioma: | No Comments »
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