SV40 enhances the risk of malignant mesothelioma among people exposed to asbestos: a molecular epidemiologic case-control study

Friday, April 15th, 2005.

Cancer Research 65, No. 8 (2005): 3049-3052. http://cancerres.aacrjournals.org/cgi/content/abstract/65/8/3049

Alfonso Cristaudo¹, Rudy Foddis¹, Agnese Vivaldi¹, Rodolfo Buselli¹, Vittorio Gattini¹, Giovanni Guglielmi¹, Francesca Cosentino¹, Franco Ottenga¹, Eugenio Ciancia², Roberta Libener³, Rosangela Filiberti⁴, Monica Neri⁴, PierGiacomo Betta³, Mauro Tognon⁵, Luciano Mutti⁶^,7 and Riccardo Puntoni⁴

Department of Endocrinology and Metabolism, Orthopedic and Traumatology, Occupational Medicine, University of Pisa;
Pathologic Anatomy Service, S.Chiara Hospital, Pisa, Italy;
Pathology Unit, Department of Oncology, Azienda Sanitaria Ospedaliera, Alessandria, Italy;
National Cancer Research Institute, Unit of Environmental Epidemiology, Genoa, Italy;
Section of Histology and Embryology,Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy;
S.Pietro e Paolo Hospital, Borgosesia, Italy; and
S.Maugeri Foundation Institute for Research and Care, Pavia, Italy

Abstract

We conducted a case-control study on asbestos exposure and presence of SV40 in tumor samples of malignant mesotheliomas (MMs) and bladder urotheliomas (BUs). PCR analysis revealed the presence of SV40 DNA (SV40+) in eight (42.1%) MMs and 6 (33.3%) BUs. The odds ratio for MM Asb– and SV40+ was 0.4 [95% confidence interval (95% CI), 0.03-4.0], for Asb+ and SV40– was 3.6 (95% CI, 0.6-21.0), and for Asb+ and SV40+ was 12.6 (95% CI, 1.2-133.9). Our results suggest that SV40 increases the risk of MM among individuals exposed to asbestos.

Glossary

oncology: (on-call-o-jee) the branch of medicine concerned with the diagnosis and treatment of cancer.
epidemiology: (ep-uh-deem-ee-AHL-uh-gee) the study of diseases in populations by collecting and analyzing statistical data. In the field of cancer, epidemiologists look at how many people have cancer; who gets specific types of cancer; and what factors (such as environment, job hazards, family patterns, and personal habits, such as smoking and diet) play a part in the development of cancer.
DNA: (dee-ok-see-ri-bo-new-CLAY-ic) abbreviation for deoxyribonucleic acid. DNA holds genetic information on cell growth, division, and function.
cancer: malignancy; a group of diseases typified by abnormal, generally out-of-control, cell growth.
tumor: an abnormal lump or mass of tissue. Tumors can be benign (not cancerous) or malignant (cancerous).

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