August 24th, 2004. Effect of inhibition of multiple steps of angiogenesis in syngeneic murine pleural mesothelioma
Conclusions: In this murine model, inhibiting multiple mechanisms of angiogenesis using two agents is a more effective antineoplastic strategy than using either agent alone. In addition, instillation of antiangiogenic gene transfer vectors into the pleural space does not result in histologic evidence of pulmonary emphysema.
