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Curated Journal Articles on Mesothelioma

Four-miRNA signature to identify asbestos-related lung malignancies.

Cancer Epidemiology, Biomarkers, & Prevention 2018 September 26 [Link]

Santarelli L, Gaetani S, Monaco F, Bracci M, Valentino M, Amati M, Rubini C, Sabbatini A, Pasquini E, Zanotta N, Comar M, Neuzil J, Tomasetti M, Bovenz

Abstract

BACKGROUND:
Altered miRNA expression is an early event upon exposure to occupational/environmental carcinogens; thus, identification of a novel asbestos-related profile of miRNAs able to distinguish asbestos-induced cancer from cancer with different ethiology can be useful for diagnosis. We therefore performed a study to identify miRNAs associated with asbestos-induced malignancies.
METHODS:
Four groups of patients were included in the study, including patients with asbestos-related (NSCLCAsb) and asbestos-unrelated non-small cell lung cancer (NSCLC) or with malignant pleural mesothelioma (MPM), and disease-free subjects (CTRL). The selected miRNAs were evaluated in asbestos-exposed population.
RESULTS:
Four serum miRNAs, i.e. miR-126, miR-205, miR-222 and miR-520g, were found to be implicated in asbestos-related malignant diseases. Notably, increased expression of miR-126 and miR-222 were found in asbestos-exposed subjects, and both miRNAs are involved in major pathways linked to cancer development. Epigenetic changes and cancer-stroma cross-talk could induce repression of miR-126 to facilitate tumor formation, angiogenesis and invasion.
CONCLUSIONS:
This study indicates that miRNAs are potentially involved in asbestos-related malignancies, and their expression outlines mechanism(s) whereby miRNAs may be involved in an asbestos-induced pathogenesis.
IMPACT:
The discovery of a miRNA panel for asbestos-related malignancies would impact on occupational compensation and may be utilized for screening asbestos-exposed populations.i M

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