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Curated Journal Articles on Mesothelioma

Illumination profile characterization of a light device for the dosimetry of intra-pleural photodynamic therapy for mesothelioma

Photodiagnosis and photodynamic therapy 2016 September 1 [Epub ahead of print] [Link]

Munck C, Mordon S, Betrouni N

Abstract

BACKGROUND:
Complete and homogeneous illumination of the pleural cavity is essential to the success of photodynamic therapy (PDT) for mesothelioma, but remains a challenge. Knowing the repartition and propagation of light around the light applicator could be the first step towards optimizing dosimetry. Here we propose a characterization method of the illumination profile of a specific light device.
METHODS:
The light wand, made of a cylindrical diffuser located inside an endotracheal tube, was fixed in a tank filled with dilute 0.01% intralipid. Light dosimetry was performed around the tip of the wand using two complementary methods: direct measurements of light power with an isotropic probe and measurements of light distribution characterization.
RESULTS:
Dosimetry with the isotropic probe showed an ellipse-shaped illumination. An optimized effective attenuation coefficient was deduced. Combined with the spatial representation, a theoretical illumination profile was established with iso-surfaces of fluence rate, defining a gradient light dose according to the distance from the diffuser.
CONCLUSION:
A theoretical illumination profile of a light device was established and could be part of an intra-operative dosimetry system to improve light delivery during intrapleural PDT.

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