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Curated Journal Articles on Mesothelioma

Malignant pleural mesothelioma: initial experience in integrated 18F-FDG PET/MR imaging

Clinical Imaging 2016 May 11 [Epub ahead of print] [Link]

Schaarschmidt BM, Sawicki LM, Gomez B, Grueneisen J, Hoiczyk M, Heusch P, Buchbender C.

Asbstract

PURPOSE:
This study aims to compare staging results of 18F-FDG PET/computed tomography (CT) and integrated PET/magnetic resonance (MR) in malignant pleural mesothelioma (MPM) patients and to investigate a potential apparent diffusion coefficient (ADC)/SUV correlation.
MATERIALS AND METHODS:
Six patients with MPM underwent 18F-FDG PET/CT and PET/MR including diffusion-weighted imaging. Thoracic TNM staging was performed for both modalities. SUV and ADC were assessed in therapy-naive pleural lesions.
RESULTS:
In thoracic TNM staging, no differences were found between PET/CT and PET/MR. An inverse correlation was observed between SUVmean and ADCmin (r=-0.63, P=.002).
CONCLUSION:
MPM can be staged using PET/MR. The inverse correlation ADC/SUV indicates that future research on multiparametric therapy response evaluation may be warranted.

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