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Curated Journal Articles on Mesothelioma

Primary yolk sac tumor of the omentum: a case report and review of the literature

Archives of Gynecology and Obstetrics. 2008 Jul 22. [Epub ahead of print] [Link]

Kim SW, Park JH, Lim MC, Park JY, Yoo CW, Park SY.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea.

Abstract

Background: Extraovarian yolk sac tumors (YSTs) arising in the omentum represent an exceedingly rare malignancy.

Case: A 37-year-old Korean woman was admitted with a history of lower abdominal pain of 3 weeks duration. Pelvic computerized tomography (CT) scanning reported a bilateral ovarian malignancy with peritoneal seeding. Exploration findings revealed a greater omental mass and the result of frozen biopsy was adenocarcinoma or mesothelioma. She was treated with supracolic omentectomy, bilateral salpingo-oophorectomy, pelvic and paraaortic lymph node dissection, multiple peritoneal biopsies and appendectomy. Histological evaluation of the specimen after operation exhibited typical patterns of YST and stained for alpha-fetoprotein (AFP) and cytokeratin. Four courses of bleomycin, etoposide, and cisplatin (BEP) combination chemotherapy repeated every 3 weeks were added to therapy and she has remained free of disease for 1 year after completion of the therapy.

Conclusion: To our knowledge this is the fourth case of primary omental YST. A review of the literature indicates that the diagnosis of
YST requires proper evaluations of tumor makers and a skilled pathologist for analysis of frozen sections.

Keywords: Yolk sac tumor – Omentum

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